Q12 Consider a membrane that has a very high content of phosphatidic acid on the inner leaflet of themembrane (the side of the membrane in contact with the cytosol). For an a-helical protein thatspans this membrane:[Select][Select]membrane[Select]✓[Select]SerHisLeumembrane and interact with phosphatidic acidmembraneConsider a membrane that has a very high content of phosphatidic acid on the inner leaflet of themembrane (the side of the membrane in contact with the cytosol). For an a-helical protein thatspans this membrane:[Select][Select]✓ [Select ]GlnValPheI screet]would likely be in the center of the membranewould likely be associated with the extracellular side of themembrane and interact with phosphatidic acidwould likely be associated with the intracellular side of theConsider a membrane that has a very high content of phosphatidic acid on the inner leaflet of themembrane (the side of the membrane in contact with the cytosol). For an a-helical protein thatspans this membrane:[Select][Select]membranewould likely be in the center of the membrane✓ [Select ]AspLysllewould likely be associated with the extracellular side of thewould likely be associated with the intracellular side of themembrane and interact with phosphatidic acidwould likely be in the center of the membraneConsider a membrane that has a very high content of phosphatidic acid on the inner leaflet of themembrane (the side of the membrane in contact with the cytosol). For an a-helical protein thatspans this membrane:would likely be associated with the extracellular side of thewould likely be associated with the intracellular side of thewould likely be in the center of the membranewould likely be associated with the extracellular side of thewould likely be associated with the intracellular side of thehosphatidic acid

Introduction Proteins are made up of amino acids. Protein plays various function in our body. Two…

Answered: Consider a membrane that has a very…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Explain how can one predict the number of transmembrane domains (TM helices) in an integral membrane protein. Note: For the above question, I only seek for an original answer no more than six sentences.
Transmembrane portrudes on both sides. Integral protein is in the width of the bilayer and may portrude on one or both sides of the bilayer. Is Transmembrane Protein semi-similar to Integral Proteins? How can we tell the difference of the two?
Researchers have discovered a new membrane protein that has three transmembrane domain αhelixes that span the lipid bilayer.a. If the lipid bilayer is 30 Å thick, what is the smallest number of amino acid residues thatcan be in each α-helixes for them to be long enough to span the bilayer?
Which of these structures would you expect to find as part of the transmembrane portion of an integral membrane protein? Structure B would be part of the transmembrane domain of an integral membrane protein. Structure C would be part of the transmembrane domain of an integral membrane protein. Structure A would be part of the transmembrane domain of an integral membrane protein.
Proteins may be bound to the exoplasmic or cytosolic face of the plasma membrane by way of covalently attached lip- ids. What are the three types of lipid anchors responsible for tethering proteins to the plasma membrane bilayer? Which type is used by cell surface proteins that face the external medium? By glycosylated proteoglycans?
Three mechanisms by which membrane-bind-ing proteins bend a membrane are illustrated in FigureQ10–2A, B, and C. As shown, each of these cytosolic mem-brane-bending proteins would induce an invagination ofthe plasma membrane. Could similar kinds of cytosolicproteins induce a protrusion of the plasma membrane(Figure Q10–2D)? Which ones? Explain how they mightwork.
The plasma membrane of E. coli is about 75% protein and 25% phospholipid by weight. How many molecules of membrane lipid are present for each molecule of membrane protein? Assume an average protein Mr of 50,000and an average phospholipid Mr of 750. What more would you need to know to estimate the fraction of the membrane surface that is covered by lipids?
Sequence analysis of a membrane protein shows four 20-amino acid long stretches of residues that are predominantly hydrophobic. Between each of these stretches of hydrodophobic residues, a stretch of predominantly hydrophilic residues is found. From this observation one can reasonably postulate that: A. this is a peripheral membrane protein which interacts with the membrane via hydrophobic interactions B. this protein has 4 alpha helical segments that span the membrane C. this protein can be removed from the membrane by dramatically increasing the salt concentration. D. this is a 4 stranded beta barrel which spans the membrane E. this is a glycoprotein
Sequence analysis of a membrane protein shows four 20-amino acid long stretches of residues that are predominantly hydrophobic. Between each of these stretches of hydrodophobic residues, a stretch of predominantly hydrophilic residues is found. From this observation one can reasonably postulate that: A. this is a peripheral membrane protein which interacts with the membrane via hydrophobic interactions B. this protein has 4 alpha helical segments that span the membrane C. this protein can be removed from the membrane by dramatically increasing the salt concentration. D. this is a 4 stranded beta barrel which spans the membrane E. this is a glycoprotein Facilitated diffusion (passive transport) through a biological membrane is A. driven by a concentration gradient. B. generally irreversible. C. endergonic. D. driven by the ATP to ADP conversion
In the "fluid " _______ cell membrane model, lipids are organized in a ________ arrangement, such that _______ portions of the lipids are exposed to either the interior or exterior of the cell, while the lipid portions are sandwiched in the middle of the membrane. As part of the cell membrane, a main function of peripheral proteins is to provide _________ , while a main function of proteins is to provide _________ . Other cell membrane molecules include a compound called __________, which functions to provide fluidity to rigid membranes and rigidity to fluid membranes; and surface carbohydrates, which function in the membrane not to provide energy, but instead to provide _________ _____ . Aminophospholipids (including PE and ) move to the inner leaflet of the membrane, by an enzyme known as the ._______ A main function of the cell membrane is to be very selective as to what is able to cross through, a condition known as a barrier.
Besides lipid molecules, cell membranes also contain many different types of proteins, each with specific functions. In the following table, select the common type of membrane protein in the right-hand column that each statement in the left-hand column describes. The choices on the Type of Membrane Protein are the same for theFunction of the Membrane Protein
Of the following cell membrane lipids, which one prefers to reside in the inner leaflet (or inner half) of the membrane bilayer, AND has an overall neutral charge at physiological pH (7.4)? a) PE (phosphatidylethanolamine) is inner-leaflet with an overall neutral charge at pH 7.4 b) SM (sphinogomyelin) is inner-leaflet with an overall neutral charge at pH 7.4 c) PS (phosephatidylserine) is inner-leaflet with an overall neutral charge at pH 7.4 d) PC (phosphatidylcholine) is inner-leaflet with an overall neutral charge at pH 7.4

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