Describe the role of mitochondria in initiating apoptosis? Please answer the question according to the picture.please answer one short paragraph only. if you can make it in bullet points that would be great.please only short answer including points stated in the attached slide. The MitochondriaPlay an InitiatingRole in ApoptosisDNAdamageCytochrome cApaf-1 (apoptosisprotease activatingfactor-1)Procaspase-9monomers(inactive)StressMeATPApoptosome causes dimer-ization of procaspase-9,creating active caspase-9dimers.ROS DevelopmentalsignalPermeability transitionpore complex opens.Procaspase-3Procaspase-7 caspase-7.Cytochrome cmoves to cytosol.Binding of cytochrome cand ATP induces Apaf-1 toform an apoptosome.ApoptosomeCaspase-9 catalyzesproteolytic activationof caspase-3 andCaspase-9dimers(active)These caspases lead to deathand reabsorption of the cell.Caspase-3Caspase-7Cell death

Often called the powerhouse of the cell, mitochondria are a double-membraned cell organelle found in…

Describe the role of mitochondria in initiating apoptosis? Please answer the question according to the picture. please answer one short paragraph only. if you can make it in bullet points that would be great. please only short answer including points stated in the attached slide.

Describe the role of mitochondria in initiating apoptosis? Please answer the question according to the picture. please answer one short paragraph only. if you can make it in bullet points that would be great. please only short answer including points stated in the attached slide.

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter21: Photosynthesis

Section: Chapter Questions

Problem 5P: The Relative Efficiency of ATP Synthesis in Noncyclic versus Cyclic Photophosphorylation If...

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Question

Describe the role of mitochondria in initiating apoptosis?

Please answer the question according to the picture.

please answer one short paragraph only. if you can make it in bullet points that would be great.

please only short answer including points stated in the attached slide.

The Mitochondria
Play an Initiating
Role in Apoptosis
DNA
damage
Cytochrome c
Apaf-1 (apoptosis
protease activating
factor-1)
Procaspase-9
monomers
(inactive)
Stress
Me
ATP
Apoptosome causes dimer-
ization of procaspase-9,
creating active caspase-9
dimers.
ROS Developmental
signal
Permeability transition
pore complex opens.
Procaspase-3
Procaspase-7 caspase-7.
Cytochrome c
moves to cytosol.
Binding of cytochrome c
and ATP induces Apaf-1 to
form an apoptosome.
Apoptosome
Caspase-9 catalyzes
proteolytic activation
of caspase-3 and
Caspase-9
dimers
(active)
These caspases lead to death
and reabsorption of the cell.
Caspase-3
Caspase-7
Cell death

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