How can human females and males function normally, despite carrying different umbers of the X chromosome? Females compensate for their double genetic dose of X chromosome, by tightly condensing one X chromosome in each cell into a Barr body, making it inactive
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- Why is it that so many of the sex-linked traits we talk about in humans are carried on X chromosomes - but are expressed mostly in males?In mammals, males have X and Y sex chromosomes, while females have two Xs. While the Y sex chromosome has very few genes associated with it, the X sex chromosome has many that are important to maintain life. How do mammals account for this in terms of equaling out gene expression levels? A. Mammals do not need to account for this, but birds do. B. Females produce more proteins from X-linked genes than males do. C. The single X of the males works twice as hard to keep up with the female’s two Xs. D. The females have one X inactivated to permit the males to keep pace with them.Which of the following statements is correct regarding the human X chromosomes? It is the same size as other chromosomes and has the same number of genes. It is present in every somatic cell of males and females. It carries genes that determine an individual's biological sex. It is referred to as an autosome.
- The gene for the production of eye colour in this species of fruit fly can be expressed aseither normal red-eyes or as brown-eyes. The allele for the normal red eyes is dominant tothat of brown, and is transmitted in normal Mendelian fashion.A gene involved with body colour in this species of fruit fly is located on the non-homologousportion of the X chromosome, and has two alleles, grey and yellow, where the grey allele isdominant to yellow.The two genes are NOT linked.a) Produce a key to clearly show the nature of the alleles associated with the eye colour inthis species of Drosophila, and in each case justify your choice of letters and / or style ofpresentation to best depict the genetics involved.What is a Barr body? How is its structure different from that ofother chromosomes in the cell? How does the structure of a Barrbody affect the level of X-linked gene expression?Which of the following statements regarding X-inactivation is TRUE?(posted) Inactivated X chromosomes are only found in somatic cells of females. After X-inactivation happens in a cell, all daughter cells resulting from mitotic events of that cell will have the same X chromosome ina none of the statements listed here are true X-inactivation is a random event that happens during human development right before a fetus is born. all of the statements listed here are true)
- Clark Kent and Lois Lane Kent are about to have a (Super) baby. As Superman, Clark possesses amazing traits, including heat-ray vision. Assume that this is: a) a dominant trait, and b) carried on the X chromosome. If Clark and Lois have a boy or a girl, what is the probability that they will possess their father's amazing abilities? (Remember: females have XX chromosomes, while males have XY chromosomes. The Y chromosome doesn’t carry any of the genes on the X chromosome). X H = Superman’s heat-ray vision allele on his X chromosome Y = Superman’s Y chromosome X h = Lois’s normal vision allele on her X chromosomeDescribe when X-chromosome inactivation occurs and how thisleads to phenotypic results at the organism level. In your answer,you should explain why XCI causes results such as variegated coatpatterns in mammals. Why do two different calico cats have theirpatches of orange and black fur in different places? Explainwhether or not a variegated coat pattern due to XCI could occur inmarsupials.You are interested in the expression of regions of the X chromosome at different times in human fetal development. You hypothesize that large regions of the X chromosomes will be expressed at times when parts of the reproductive organs are developing. What structural and chemical characteristics of the X chromosome might you look at over time to determine when expression of genes on the X chromosome is enhanced or repressed?
- . In humans, hemophilia is an X-linked recessive gene and will only be expressed in females if they are homozygous for this gene. However, in some rare cases, a heterozygote becomes hemophilic. Explain how this incident happens and why will there be skewed X-inactivation?In dosage compensation, do males sometimes overcompensate or is it always Barr body X-chromosome inactivation for females?Equalizing the Expression of X Chromosome Genes in Males and Females Individuals with an XXY genotype are sterile males. If one X is inactivated early in embryogenesis, the genotype of the individual effectively becomes XY. Why will this individual not develop as a normal male?