If you were to determine the P/O ratio for oxidation of a-ketoglutarate, you would probably include some malonate in your reaction system. Why? Under these conditions, what P/O ratio would you expect to observe?
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- Examine the ActiveModel for alcohol dehydrogenase and describe the structure and function of the catalytic zinc center.If you were to determine the P/O ratio for oxidation of a-ketoglutarate, you would probably include some malonate in your reaction system. Why? Under these conditions, what P/O ratio would you expect to observe?If you were to determine the P/O ratio for oxidation of α-ketoglutarate,you would probably include some malonate in your reaction system. Why?Under these conditions, what P/O ratio would you expect to observe?
- Intestinal microbes produce butyrate, which helps regulate the immune system. How many rounds of β oxidation of palmitate are required to produce butyrate?Are any of the intermediates in the β-oxidation pathway chiral? Explain.Why is the glyoxylate cycle necessary for growth on acetate butnot on succinate?
- With H2 as electron donor, why is reduction of Fe3+ a morefavorable reaction than reduction of fumarate?In order to function as an oxidative phosphorylation uncoupler, 2,4-dinitrophenol must act catalytically, not stoichiometrically. What does this mean? Identify and discuss an important implication of this conclusion.In some brain cancer cells, a mutated form of isocitrate dehydrogenase, instead of catalyzing the oxidation of the secondary alcohol of isocitrate, catalyzes the reduction of a-ketoglutarate. Draw the product of the reaction.