In Grignard reagent with bromobenzene and acetophenone, how would the reaction change if a student used ethanol as the solvent rather thandiethyl ether?Dihydropyridinbenzene would be the isolated productethylbenzene would be the isolated productHow can we cet would be an effective calcium channel blocker?the product would be unchanged, but the reaction rate would increaseDihydropyridines arebecauseHow can we change priveledged structurespyridines we made so that the product would be an effective calcium channel blocker?pharmacophoreDihydropyridines arebecausecium channel blocker?they tend to be biologically active and their biological target depends on what else is around them in the moleculethey have the necessary bonding interactions to hit the enzymeHow can we change the synthesis of the dihydropyridines we made so that the product would be an effective calcium channel blocker?change the aldehyde wechange the beta-keto esterchange the amine

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In Grignard reagent with bromobenzene and acetophenone, how would the reaction change if a student used ethanol as the solvent rather than diethyl ether? Dihydropyridir benzene would be the isolated product ethylbenzene would be the isolated product How can we c et would be an effective calcium channel blocker? the product would be unchanged, but the reaction rate would increase

In Grignard reagent with bromobenzene and acetophenone, how would the reaction change if a student used ethanol as the solvent rather than diethyl ether? Dihydropyridir benzene would be the isolated product ethylbenzene would be the isolated product How can we c et would be an effective calcium channel blocker? the product would be unchanged, but the reaction rate would increase

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter11: Ethers, Epoxides, And Sulfides

Section: Chapter Questions

Problem 11.18P

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Imagine that phenol (“hydroxybenzene”) and nitrobenzene are reacted (in separate beakers) with a hot solution containing both concentrated sulfuric acid and concentrated nitric acid. A) In analyzing the products, you discover that the substitution pattern resulting from the reaction with phenol differs from the reaction with nitrobenzene. Explain this difference in substitution patterns using one or more judiciously selected reaction mechanisms or portions of mechanisms.
The following substances can be prepared by a nucleophilic addition reaction between an aldehyde or ketoneand a nucleophile. Identify the reactants from which they were prepared. If the substance is an acetal, identifythe carbonyl compound and the alcohol; if it is an imine or enamine, identify the carbonyl compound and theamine. You do not have to consider stereochemistry. In cases where there is more than one answer, just giveone. Use Grignard reagents when an organometallic reagent is required. Draw the Grignard reagent as acovalent magnesium bromide.
The Stork reaction is a condensation reaction between an enamine donor and an α,β-unsaturated carbonyl acceptor. The overall reaction consists of a three-step sequence of formation of an enamine from a ketone, Michael addition to an α,β-unsaturated carbonyl compound, and hydrolysis of the enamine in dilute acid to regenerate the ketone. Consider the Stork reaction between cyclohexanone and propenal Draw the structure of the product of the enamine formed between cyclohexanone and dimethylamine. - Michael addition to an α,β-unsaturated carbonyl compound, and - hydrolysis of the enamine in dilute acid to regenerate the ketone.
In an experiment, triphenylmethanol is prepared using the Grignard reaction. The Grignard reaction involves preparation and reaction of a very nucleophilic organo-magnesium compound. The Grignard reagent is very reactive and is easily destroyed by reaction with atmospheric water, oxygen, or carbon dioxide. The Grignard reagent must be prepared under strict anhydrous conditions (dry glassware, dry solvent). The volative solvent, diethyl ether, helps to prevent oxygen or carbon dioxide from entering the reaction vessel. Reaction of bromobenzene with magnesium in ether produces phenylmagnesium bromide. This Grignard reagent then reacts with methyl benzoate to produce the corresponding alkoxide. Reaction of the alkoxide with aqueous acid then produces the alcohol. Why does pressure develop when the separatory funnel containing aqueous sulfuric acid and the ethereal solution of organic products is shaken?
In an experiment, triphenylmethanol is prepared using the Grignard reaction. The Grignard reaction involves preparation and reaction of a very nucleophilic organo-magnesium compound. The Grignard reagent is very reactive and is easily destroyed by reaction with atmospheric water, oxygen, or carbon dioxide. The Grignard reagent must be prepared under strict anhydrous conditions (dry glassware, dry solvent). The volative solvent, diethyl ether, helps to prevent oxygen or carbon dioxide from entering the reaction vessel. Reaction of bromobenzene with magnesium in ether produces phenylmagnesium bromide. This Grignard reagent then reacts with methyl benzoate to produce the corresponding alkoxide. Reaction of the alkoxide with aqueous acid then produces the alcohol. Why is it unwise to begin addition of the solution of carbonyl compound to the Grignard reagent before the latter has cooled to room temperature?
In an experiment, triphenylmethanol is prepared using the Grignard reaction. The Grignard reaction involves preparation and reaction of a very nucleophilic organo-magnesium compound. The Grignard reagent is very reactive and is easily destroyed by reaction with atmospheric water, oxygen, or carbon dioxide. The Grignard reagent must be prepared under strict anhydrous conditions (dry glassware, dry solvent). The volative solvent, diethyl ether, helps to prevent oxygen or carbon dioxide from entering the reaction vessel. Reaction of bromobenzene with magnesium in ether produces phenylmagnesium bromide. This Grignard reagent then reacts with methyl benzoate to produce the corresponding alkoxide. Reaction of the alkoxide with aqueous acid then produces the alcohol. Ethanol is often present in the technical grade of diethyl ether. If this grade rather than anhydrous were used, what effect, if any, would the ethanol have on the formation of the Grignard reagent? Explain.
p-Fluoronitrobenzene is more reactive toward hydroxide ion than is p-chloronitrobenzene. What does this tell you about the rate-determining step for nucleophilic aromatic substitution?
Which of the following statements about substituent effect in electrophilic aromatic substitution reactions (E.A.S.) is false? Electron-withdrawing groups (EWGs) passivates the benzene ring for ortho and para substitution Carbonyl group which are bonded directly to the ring are called electron withdrawing groups (EWGs) In nitration of benzaldehyde, major products are ortho and para-nitro benzaldehyde Regioselectivity in multiple subtitution is determined by the substituent which has a higher activation effect F, Cl, Br, and I are orto-para directing groups, but have passivating effect
The Stork reaction is a condensation reaction between an enamine donor and an α,β-unsaturated carbonyl acceptor. The overall reaction consists of a three-step sequence of formation of an enamine from a ketone, Michael addition to an α,β-unsaturated carbonyl compound, and hydrolysis of the enamine in dilute acid to regenerate the ketone. Consider the Stork reaction between acetophenone and 3-buten-2-one. Draw the structure of the product of the enamine formed between acetophenone and pyrrolidine. Draw the structure of the Michael addition product. Draw the structure of the final product.
Explain WHY/HOW all please - Propanol CANNOT protonate ethylamine - 3-methylheptan-3-ol CANNOT be produced from the reaction of an ester with a Grignard reagent - Carbonic acid is dissolved in water, the equilibrium of its dissociation will have a Keq value = between 0 and 1 - Pentane is less soluble in water than octane - Dehydration of pentan-2-ol to produce pent-2-ene which involves heating: values of Keq = between 0 and 1 and ΔG = > 0 - The molecule cis-1-ethyl-3-iodocyclohexane CANNOT adopt a chair conformation in which there are no equatorial groups.
Explain why hydroxide ion catalyzes the reaction of piperidine with 2,4-dinitroanisole but has no effect on the reaction of piperidine with 1-chloro-2,4-dinitrobenzene.
The reaction that occurs when the benzaldehyde you have is reacted in a basic environment is called the Cannizzaro reaction, and when it is reacted with cyanide, it is called benzoin. It Explain the reason by writing the reaction mechanisms of the reactions.