Which metabolites can potentially accumulate when complex I of the electron transport chain is defective?

Human Physiology: From Cells to Systems (MindTap Course List)
9th Edition
ISBN:9781285866932
Author:Lauralee Sherwood
Publisher:Lauralee Sherwood
Chapter2: Cell Physiology
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Problem 10RE: Using the answer code on the right, indicate which form of energy production is being described: 1....
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. In the section dealing with “NAD+ in disease” it is mentioned that metabolomics results
indicate that impaired mitochondrial function contributes to some of the mentioned
diseases. Which metabolites can potentially accumulate when complex I of the
electron transport chain is defective? 

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