In the section dealing with “NAD+ in disease” it is mentioned that metabolomics resultsindicate that impaired mitochondrial function contributes to some of the mentioneddiseases. Which metabolites can potentially accumulate when complex I of theelectron transport chain is defective? Use Fig 1 for guidance Alcohol metabolismGiycolysisGAPDHLactic acid fermentationERGlucosePyruvateLDH LactateGluconeogenesisLactate oxidation(Cori cycle)OAAEthanolMDHADHMalateD5D/D6DPUFA+ HUFAAcetaldehydePUFA desaturationCytosolAcetaldehydeETCNADHPyruvateALDH* NAD*PDCIMSAcetateAcetyl-CoACyt cyHADH-ADP + P,OA-MDHB-oxidation Acyl-COA►ATPLMalateDHTCA cyclea-KGDHMitochondrial matrix

In the section dealing with “NAD+ in disease” it is mentioned that metabolomics results indicate that impaired mitochondrial function contributes to some of the mentioned diseases. Which metabolites can potentially accumulate when complex I of the electron transport chain is defective? Use Fig 1 for guidance

In the section dealing with “NAD+ in disease” it is mentioned that metabolomics results indicate that impaired mitochondrial function contributes to some of the mentioned diseases. Which metabolites can potentially accumulate when complex I of the electron transport chain is defective? Use Fig 1 for guidance

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter22: Gluconeogenesis, Glycogen Metabolism, And The Pentose Phosphate Pathway

Section: Chapter Questions

Problem 11P: Understanding the Mechanisms of Reactions Related to Transketolase The mechanistic chemistry of the...

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