Sharpless Asymmetric DihydroxylationDihydroxylation of alkenes is an addition reaction that converst alkene to a vicinal diol. It was de-veloped in the 1970 by chemists at the Upjohn Company. Couple of decades later an asymmetricversion of this reaction was developed by K. Barry Sharpless, who was later awarded Nobel Prize inChemistry for that work. Do a web search for Sharpless Asymmetric Dihydroxylation and use theinformation youfind to answer the questions below. 2. Look up the model that is used to predict stereochemical outcome of Sharpless asymmetricdihydroxylation. Demonstrate how the model is applied by predicting the outcome of dihy-droxylation of the reaction shown below.3. The discoverer of the dihydroxylation reaction, prof. K. Barry Sharpless, is blind on one eye.Investigate this fact and describe in a short paragraph.ОНAD-mix BОНFigure 1: Sharpless Asymmetric Dihydroxylation

"Since you have asked multiple questions, we will solve the first question for you. If you want any…

Look up the model that is used to predict stereochemical outcome of Sharpless asymmetric dihydroxylation. Demonstrate how the model is applied by predicting the outcome of dihy- droxylation of the reaction shown below.

Look up the model that is used to predict stereochemical outcome of Sharpless asymmetric dihydroxylation. Demonstrate how the model is applied by predicting the outcome of dihy- droxylation of the reaction shown below.

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter13: Substitution

Section: Chapter Questions

Problem 4E

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Question

Sharpless Asymmetric Dihydroxylation
Dihydroxylation of alkenes is an addition reaction that converst alkene to a vicinal diol. It was de-
veloped in the 1970 by chemists at the Upjohn Company. Couple of decades later an asymmetric
version of this reaction was developed by K. Barry Sharpless, who was later awarded Nobel Prize in
Chemistry for that work. Do a web search for Sharpless Asymmetric Dihydroxylation and use the
information you
find to answer the questions below.

2. Look up the model that is used to predict stereochemical outcome of Sharpless asymmetric
dihydroxylation. Demonstrate how the model is applied by predicting the outcome of dihy-
droxylation of the reaction shown below.
3. The discoverer of the dihydroxylation reaction, prof. K. Barry Sharpless, is blind on one eye.
Investigate this fact and describe in a short paragraph.
ОН
AD-mix B
ОН
Figure 1: Sharpless Asymmetric Dihydroxylation

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