Но. NH HO. IN: N' бн он trabectedin Il.

EBK A SMALL SCALE APPROACH TO ORGANIC L
4th Edition
ISBN:9781305446021
Author:Lampman
Publisher:Lampman
Chapter20: Nucleophilic Substitution Reactions: Competing Nucleophiles
Section: Chapter Questions
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Trabectedin, shown in a ball-and-stick model on the cover of this text, is an anticancer drug sold under the trade name Yondelis.

a. Locate the stereogenic centers in trabectedin.

b.What is the maximum number of stereoisomers possible for trabectedin?

c.Draw the enantiomer.

d.Draw a diastereomer.

e.If the specific rotation of trabectedin is +41.5, what is the [α] of a solution that contains 75% trabectedin and 25% of its enantiomer?f

. What is the ee of a solution with [α] = +10.5?

Но.
NH
HO.
IN:
N'
бн
он
trabectedin
Il.
Transcribed Image Text:Но. NH HO. IN: N' бн он trabectedin Il.
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