Problem 2. Competitive inhibitors are commonly used to make pharmaceuticals. Some cancer drugs act ascompetitive inhibitors to reduce the undesired effects of oncogenic kinases. The figure below shows V-Sprofiles of a kinase enzyme in the presence of two different inhibitors (Ij and I) competing with the substrate.The enzyme parameters, Km and Vmax, are known to be 0.8 and 1.2 nM/s, respectively. Determine Equilibriumconstants, K1 and K2, associated with the first and second inhibitors.0.70.60.50.40.3--0.1nM 11+0.1nM 12..... 0.15nM 11 +0.05nM 120.20.10.51.522.53.5[S] (nM)(s/wu) °A

We need to plot the Lineweaver Burk Plot (LB Plot) to solve this problem. So first we need to find…

Answered: Problem 2. Competitive inhibitors are…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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