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- Both karyotyping and G_banding techniques show normal chromosomal pattern, however pedigree analysis revealed abnormality of genetic origin, can you think of a reason that would explain the findings?Both karyotyping and G_banding techniques show normal chromosomal pattern, however pedigree analysis revealed abnormality of genetic origin, what are the reasons of this?A woman who sought genetic counseling is found to be heterozygousfor a chromosomal rearrangement between the second andthird chromosomes. Her chromosomes, compared to those in anormal karyotype, are diagrammed on the next page:(a) What kind of chromosomal aberration is shown?
- The results of a paternity test using short tandem repeatsare listed in the table below. Who’s the daddy? How sureare you?A woman who sought genetic counseling is found to be heterozygousfor a chromosomal rearrangement between the second andthird chromosomes. Her chromosomes, compared to those in anormal karyotype, are diagrammed on the next page:(a) This woman is phenotypically normal. Does thissurprise you? Why or why not? Under what circumstancesmight you expect a phenotypic effect of such arearrangement?Which members of the pedigree could have been carriers, and which might have been the source of the mutation?
- Familial retinoblastoma, a rare autosomal dominant defect, arose in a large family that had no prior history of the disease. Consider the following pedigree (the darkly colored symbols represent affected individuals): a. Circle the individual(s) in which the mutation most likely occurred. b. Is the person who is the source of the mutation affected by retinoblastoma? Justify your answer. c. Assuming that the mutant allele is fully penetrant, what is the chance that an affected individual will have an affected child?Phenylketonuria and alkaptonuria are both autosomal recessive diseases. If a person with PKU marries a person with AKU, what will the phenotype of their children be?Pedigree Analysis Is a Basic Method in Human Genetic: What are the reasons that pedigree charts are used?
- Over 300 genetic defects can be detected now by examining a karyotype. Its true or false? ExplainFor genes that are close together, the frequencies ofcotransformation or cotransduction are inversely relatedto the distance between the ___Many genetic disorders exhibit locus heterogeneity. Define andgive two examples of locus heterogeneity. How does locus heterogeneityconfound a pedigree analysis?