Answered: SH2 domains bind phosphotyrosine…

SH2 domains bind phosphotyrosine residues in deep pockets on their surfaces. Would you expect SH2 domains to bind phosphoserine and phosphothreonine with high affinity? Why or why not?

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter32: The Reception And Transmission Of Extracellular Information

Section: Chapter Questions

Problem 11P

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Metabolic pathways

Metabolism is defined as the group of life-supporting, enzyme-mediated chemical reactions in organisms. A metabolic pathway is a set of these chemical reactions that involve anabolism (synthesis of complex biomolecules) and catabolism (breakdown of biomolecules into small molecules) that occur inside a cell. Metabolites are the reacting substances, products, and intermediate substances of an enzymatic process that are altered by a series of chemical events catalyzed by enzymes.

Question

SH2 domains bind phosphotyrosine residues in deep pockets on their surfaces. Would you expect SH2 domains to bind phosphoserine and phosphothreonine with high affinity? Why or why not?

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