What type of regulation does the interaction of BPG with hemoglobin represent?
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What type of regulation does the interaction of BPG with hemoglobin represent?
Cooperativity
Homotropic allostery
Heterotropic allostery
Covalent post-translational modification
2, 3-Bisphosphoglycerate (2,3-BPG) is most abundant organic phosphate in the red blood cell. Molar concentration of 2, 3-Bisphosphoglycerate (2,3-BPG) is approximately equivalent to that of hemoglobin.
It regulates binding of oxygen to hemoglobin.
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- The allosteric regulation of ATCase by CTP is an example of: 1. Negative homotropic allostery 2. Positive homotropic allostery 3. Negative heterotropic allostery 4. Positive heterotropic allosteryAn SH2-containing protein contains a mutation that changes its binding pocket such that tyrosine and phosphotyrosine bind with equal affinity. As a result, MEK activity: does not change with receptor dimerization and transautophosphorylation decreases due to changes in Raf activation increases with ligand binding-induced dimerization decreases due to allosteric inhibition of SH2-domain bindingmTOR must be tightly regulated because it controls both transcription and translation. true or false. explain why
- Protein activity is controlled by multiple mechanisms in the cell. Briefly describe how this type of protein control is used in the cell and if this is an example of pre- or post-translational control. Allosteric activationThese are protein regulators in ER which control the proper folding of newly synthesized or misfolded proteinsTPA protein function. Use at least two sentences to describe the function of the TPA protein.
- Many blood clotting proteins undergo a post-translational modification in which specific glutamic acid residues (Glu) in the protein are converted to gamma-carboxyglutamic acid residues (Gla). See reaction scheme below. An example is the blood clotting protein Factor IX, which has 12 Glu in its N-terminus converted to Gla. This modification gives Factor IX the ability to bind calcium and phospholipid membranes. Bacteria do not have the enzyme required to convert Glu to Gla and therefore Factor IX proteins expressed in bacteria would not have the proper modifications. How might you engineer the translational apparatus of a bacterial cell line so that it produces Factor IX with Gla in the appropriate positions. How would you ensure that only the 12 Glu in Factor IX that are normally converted to Gla and not just all Glu (Limit 5-6 senetnces)?Cyclic-AMP stimulates which of the following? a) PKA b) PKC c) Ras d) RTKThe ras protein is a mutated G protein that lacks GTPase activity. How does the absence of this activity affect the adenylyl cyclase pathway?
- Some transcription factors contain bromodomains. Explain the function of the bromodomain? Please help expalin this in 5 sentences or less, thank you!Caspases are involved in ___. Select one: a. protein dephosphorylation b. programmed cell death c. cell division d. redox status of proteins e. protein synthesisThe required association of two α-globin molecules and two β-globin molecules to make a functionally active hemoglobin molecule is an example of translational control. post-transcriptional control. post-translational control. chromatin control. transcriptional control.