Sickle cell anemia is a disease caused by a mutation at the genotypic level. A person with two copies of the gene has the disease, but a person with one copy of the gene does not have the disease. The diagram shows how this mutation affects an organism.   Use the image to answer the question. The mutation causes the deformity of the red blood cell, the component of blood that carries oxygen throughout the body. The deformed cells can clump together and can clog blood vessels. The parasites responsible for the sickle cell condition are killed in the deformed red blood cells. In which type of environment would carriers of the disease be naturally selected for?   A. low altitude   B. high altitude   C. low population of parasites   D. high population of parasites

Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter29: Transcription And The Regulation Of Gene Expression
Section: Chapter Questions
Problem 6P
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Sickle cell anemia is a disease caused by a mutation at the genotypic level. A person with two copies of the gene has the disease, but a person with one copy of the gene does not have the disease. The diagram shows how this mutation affects an organism.

 

Use the image to answer the question.

The mutation causes the deformity of the red blood cell, the component of blood that carries oxygen throughout the body. The deformed cells can clump together and can clog blood vessels. The parasites responsible for the sickle cell condition are killed in the deformed red blood cells.

In which type of environment would carriers of the disease be naturally selected for?

  •  
    A.

    low altitude

  •  
    B.

    high altitude

  •  
    C.

    low population of parasites

  •  
    D.

    high population of parasites

Wild-type B-globin
Sickle-cell B-globin
Wild-type B-globin DNA
CTC
GAG
Mutant B-globin DNA
5'
13'
3'
31
CAC
15'
5
GTG
13'
MRNA
5'1
MRNA
5'
GAG
13'
GUG
13'
Normal hemoglobin
Sickle-cell hemoglobin
Val
Glu
s in
Transcribed Image Text:Wild-type B-globin Sickle-cell B-globin Wild-type B-globin DNA CTC GAG Mutant B-globin DNA 5' 13' 3' 31 CAC 15' 5 GTG 13' MRNA 5'1 MRNA 5' GAG 13' GUG 13' Normal hemoglobin Sickle-cell hemoglobin Val Glu s in
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