Sickle cell anemia is associated with which of the following: Question 27 options: Sticky patches on the hemoglobin surface only present in the T-state Sticky patches on the hemoglobin surface only present in the R-state A mutant form of hemoglobin called Ɣ-hemoglobin Decreased ability to stabilize the T-state with 2,3-bisphosphoglycerate Decreased ability to bind heme because of the Bohr effect

Sickle cell anemia : It is caused by the single acidic amino acid substitution, Glu 6th position to…

Answered: Sickle cell anemia is associated with…

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter11: The Blood

Section: Chapter Questions

Problem 1SQE

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Similar questions

Why people with PK deficiency may tolerate a lower hemoglobin level than people with other types of anemia in which 2,3-DPG is not elevated? explain as simple as possible
Cows that graze on spoiled sweet clover, which contains dicoumarol, die from hemorrhagic disease. The cause of death is defective prothrombin. However, the amino acid composition of the defective prothrombin is identical to that of normal prothrombin. What is the mechanism of action of dicoumarol? Why are the amino acid compositions of the defective and normal prothrombin the same?
What is the function of 2,3-bisphosphoglycerate (BPG)? Why do red blood cells have large amounts of BPG?
How does the difference between the-chain and the -chain of hemoglobin explain the differences inoxygen binding between Hb A and Hb F?
Relative to the position of hemoglobin A on your gel, where would you expect to find a mutant hemoglobin in which the b-chain glutamic acid residue was replaced by lysine? Sample Wall Number: 1. Normal Hemoglobin- Homoglobin AA 2. Sickle Trait Hemoglobin- Hemoglobin AS 3. Sickle Cell Hemoglobin- Hemoglobin SS 4. The unkniwn hemoglobin sample (showing the mutant sickle cell anemia trait)
Why fibrinopepetide A and fibrinopepetide B are negatively charged ?
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why is hemoglobin more soluble in water than a-keratin?
In the experiment performed for the determination of cholesterol, the function of the calibration curve obtained using 25-400mg/dL standard cholesterol solutions was determined as y= 0.0009x. If the absorbance of the serum sample is determined as 0.28, what is the amount of cholesterol in the sample, in mg/L?
What physiological effect would you predict from a mutation that replacedwith serine the cysteine in the constant part of the immunoglobulin lightchain that is involved in disulfide-bond formation with the heavy chain?(as shown)
Based on the sensitivity of DNA to DNase I, as illustrated in Figure, which type of chicken hemoglobin (embryonic or adult) is likely to be produced in the highest quantity in the following tissues and developmental stages? Q.Erythroblasts during the first 24 hours
. What would you predict to be the relative rate of synonymous and nonsynonymous substitutions in a globinpseudogene?

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	Sticky patches on the hemoglobin surface only present in the T-state
	Sticky patches on the hemoglobin surface only present in the R-state
	A mutant form of hemoglobin called Ɣ-hemoglobin
	Decreased ability to stabilize the T-state with 2,3-bisphosphoglycerate
	Decreased ability to bind heme because of the Bohr effect