Vorksheet-Mutations.DOCX目Insert Format Tools HelpLast edit was 7 minutes agoBIUA9四回~|川- |三| = m<市、 m m一x100% - Normal text| Times New...111.1 31 4Sickle cell anemia is the result of a type of mutation in the gene that codes for part of the hemoglobin molecule.Hemoglobin carries oxygen in your red bloods cells. The mutation causes these red blood cells to become stiff &sickle-shaped when they release their oxygen. The sickled cells tend to get stuck in blood vessels, causing pain andet: Deletio..increased risk of stroke, blindness, damage to the heart & lungs, and other conditions.DNA CA ..Analyze the DNA strands below to determine what amino acid is changed AND what type of mutation occurredbin DNA C.CACGTAGACT AGGACTC..Normal hemoglobin DNANormal hemoglobin MRNA:Normal hemoglobin Amino Acid sequence:Sickle cell hemoglobin DNACACGTAGACTGAGGACAC..Sickle cell hemoglobin MRNA:

Sickle-cell anemia is a genetic disease characterized by the sickle shape of the RBCs. It results in…

Answered: Sickle cell anemia is the result of a…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Central Dogma of Molecular Biology from DNA to RNA to Protein, discussing the principles underlying the transfer of information in a biologic system and its regulation. However, recent research seems to challenge certain aspects of Crick’s Central Dogma. Does the Central Dogma still stand today? If not, can you find an example for a type of information transfer that is not explicitly covered by the Central Dogma (or even violates it)?
- Multiple Choice - Explain your answer in 3-5 sentences. - answer properly QUESTION: Which of the following is false? a. Methyl, phosphoryl, adenyl, uridylyl and adenosine diphosphate ribosyl groups are the modifying groups b. An example of an enzyme regulated by methylation is the methyl-donating chemo taxis protein of bacteria c. The protein is a part of the system that permits a bacterium to swim towards attractant d. The methylating agent is S- adenosylmethionine
True or false? The most common form of Down's Syndrome results from a spontaneous, somatic, gene mutation.
Give typing answer with explanation and conclusion The following gene codes for a liver enzyme. Changing the A/T base pair to which of the following would result in a missense mutation? 5’ GCCTAATATGCCCGTATGC(AGC)nCGAATAAAATAGTACGGTCGTCGC 3’ 3’ CGGATTATACGGGCATACG(TCG)nGCTTATTTT ATCATGCCAGCAGCG5’ A. C/G B. T/A C. G/C D. Any of the above E. 2 of the above F. None of the above
Tick the correct statements: Remember: Tautomers are structural isomers that differ from each other based on the position of the proton(s) and their double bonds. ( ) The nitrogenous bases of nucleic acids, which contain heterocyclic and analogous nuclei, can adopt different tautomeric forms involving multiple H+ that are exchangeable depending on the medium. In DNA, spontaneous formation of smaller tautomers appears to contribute to mutagenic errors during DNA replication, while in RNA, they seem to be related to increased structural and functional diversity of enzymes and RNA aptamers (research this and confirm if it is false or real) ( ) in relation to the figure, anomer 1 has beta stereochemistry with respect to the C anomeric of the pentose, and is making an N-glycosidic bond ( ) in relation to the figure, anomer 1 has alpha stereochemistry with respect to the C anomeric of the pentose, and is making an N-glycosidic bond ( ) In general, in naturally occurring nucleosides,…
True or false? the buffer used during for transferring proteinsto nitrocellulose contains methanol. Transfection is a process for adding proteins directly to cellls. H2B is a type of histone.
Let’s return to your patient with sickle cell anemia. Below is the RNA sequence from your patient and from her mother. (The ••• represents another 30 nucleotides not written out here). The affected nucleotide is indicated in BOLD. Patient’s RNA: 5’ –CUAUGACAGAGUUC•••CAUUAGCCA – 3’ Mother’s RNA: 5’ –CUAUGACAGUGUUC•••CAUUAGCCA – 3’ C) Write out the sequence of the normal beta-globin protein (as much as you can given the above info and below genetic code table) and indicate what would be different in the mutant protein. Don't forget your ends!
drop down choices: - functional - non functional - no transcription
- cytogenetics- Give me an example of make up a crime scene scenario in which DNA from a nonhuman provided critical evidence.
Sickle-cell disease (often called sickle-cell anemia) is a disease that is caused by a mutation to the gene that is responsible for producing the protein hemoglobin. Remember that hemoglobin is a protein in the red blood cells which is responsible for carrying oxygen throughout the body. When a person possesses the mutated hemoglobin allele, their red blood cells take on an altered shape and this results in a variety of symptoms ranging from general weakening of the body, damage to the organs and even death. The sickle cell allele is recessive to the healthy allele, thus only individuals that are homozygous for the recessive allele will have sickle-cell disease. Individuals that are homozygous for the healthy allele, along with heterozygous, individuals will be physically healthy. Question: Given that this mutated allele will cause disease and death in individuals, what would you predict to occur to the frequency of this allele in the population? Explain.
CHOICES: Isoniazid Rifampicin Ethambutol None of the Choices Binds to bacterial DNA gyrase & topoisomerase
1. Hemoglobin researchers have discovered more than 500 naturally occurring hemoglobin mutations. The majority of these results from single amino acid changes. Some of these mutations result in clinical illness or symptoms, but many show no outward effects. Some examples are: HbS (sickle cell Hb)-substitutes Val for Glu on the surface Hb Cowtown - eliminates an ion pair used in T-state stabilization Hb Memphis - surface uncharged polar aa for another of similar size on the surface Hb Bibba-substitutes a Pro for a Leu in an α-helix Hb Milwaukee - substitutes a Glu for a Val Hb Providence- substitutes a Asn for a Lys that normally projects into the central cavity Hb Philly - substitutes a Phe for a Tyr, disrupting hydrogen bonding at the aß interface. EXPLAIN your choices for each of the following: a) The Hb variant least likely to cause pathological symptoms b) The variant(s) most likely to show pl values different from that of HbA c) The variant(s) most likely to show…

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