Please help Sickle cell disease is a medical condition involving the mutation of a single nucleotide in the HBB gene.The resulting protein affects the formation of the subunits that make up hemoglobin. People with sicklecell disease display varying dégrees of abnormal hemoglobin structures, which can then cause the redblood cells to distort into a sickle shape. This conformation can lead to medical conditions, includingvascular occlusion, pain, and anemia.This is a segment of the gene that codes for hemoglobin. The sequences below are the coding strand ofthe DNA where the mutation is found:Sequence for Wild-Type Hemoglobin5'...TACTAATCGA AAATTGCAGA CTGTAATGGA CTGTAATGGT GCACCTGACT CCTGAGGAGAAGGTAAGT......A..C CAGGCTTCTG CCGTTACTTG AGAGAAGTCT G...3'Sequence for Mutant (Sickle-Cell) Hemoglobin5'...TACTAATCGA AAATTGCAGA CTGTAATGGA CTGTAATGGT GCACCTGACT CCTGTGGAGA|AGGTAAGT......A..C CAGGCTTCTG CCGTTACTTG AGAGAAGTCT G...3'The nucleotide that is underlined and in bold indicates the start of transcription. Note that '....' Indicatesthat there are additional nucleotides that have not been included in the sequence.1- Write the mature MRNA for both sequences, indicating both the 5' and 3' ends.Use the diagram below to identify the intron consensus sequencesExon 1Exon 25' splice siteIntron3' splice site5'AAGGUGAGUCAGG3'5' consensusBranch3' consensussequencepointsequencePierce, Genetics: A Conceptual Approach, 7e © 2020 W. H. Freeman andCompany2- Then, translate both sequences of mRNA and indicate the mutated amino acid. Remember to includethe amino and carboxyl terminus in your amino acid sequence.

Sickle cell anemia is a genetic disorder that affects RBCs or Red Blood Cells. More specifically,…

Sickle cell disease is a medical condition involving the mutation of a single nucleotide in the HBB gene. The resulting protein affects the formation of the subunits that make up hemoglobin. People with sickle cell disease display varying degrees of abnormal hemoglobin structures, which can then cause the red blood cells to distort into a sickle shape. This conformation can lead to medical conditions, including vascular occlusion, pain, and anemia. This is a segment of the gene that codes for hemoglobin. The sequences below are the coding strand of the DNA where the mutation is found: Sequence for Wild-Type Hemoglobin 5'...TACTAATCGA AAATTGCAGA CTGTAATGGA CTGTAATGGT GCACCTGACT CCTGAGGAGA AGGTAAGT.....A..C CAGGCTTCTG CCGTTACTTG AGAGAAGTCT G...3' Sequence for Mutant (Sickle-CelI) Hemoglobin 5'...TACTAATCGA AAATTGCAGA CTGTAATGGA CTGTAATGGT GCACCTGACT CCTGTGGAGA| AGGTAAGT......A..C CAGGCTTCTG CCGTTACTTG AGAGAAGTCT G...3' The nucleotide that is underlined and in bold indicates the start of transcription. Note that '....' Indicates that there are additional nucleotides that have not been included in the sequence. 1- Write the mature mRNA for both sequences, indicating both the 5' and 3' ends. Use the diagram below to identify the intron consensus sequences Exon 1 Exon 2 5' splice site Intron 3' splice site 5' JAAGGU%AGU A. CAG G 3' 5' consensus Brànch 3' consensus sequence point sequence Pierce, Genetics: A Conceptual Approach, 7e © 2020 W. H. Freeman and Company 2- Then, translate both sequences of MRNA and indicate the mutated amino acid. Remember to include the amino and carboxyl terminus in your amino acid sequence.

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter10: From Proteins To Phenotypes

Section: Chapter Questions

Problem 20QP: If an extra nucleotide is inserted in the first exon of the beta globin gene, what effect will it...