The enzyme thiolase catalyzes one step in the ß-oxidation of saturated fats. One portion of the mechanism for this reaction is shown below. Describe the catalytic mechanism at work. (Note: "SCOA" is shorthand for the compound Acetyl-CoA) RCOCH₂COSCOA + HSCOA → H3C₂OSC0A + RCOSCOA

Anatomy & Physiology
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Author:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Publisher:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Chapter24: Metabolism And Nutrition
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8. The enzyme thiolase catalyzes one step in the ß-oxidation of saturated fats. One portion of the
mechanism for this reaction is shown below. Describe the catalytic mechanism at work.
(Note: "SCOA" is shorthand for the compound Acetyl-CoA)
RCOCH₂COSCoA + HSCOA → H3C₂OSC0A + RCOSCOA
HN NH
CH₂
NH
CH₂
CH₂
FS
Grease
NH3
H-SCO A
NH
CH2
CH₂
NH3
S Co A
CH₂
NH
1
3
H-SCO A
H3C
SCO A
NH3
a h-SCOA
R-C
S Co A
CH₂
CH₂
C
H₂
0=0
HN NH
+
NH3
H₂C
HN
CH₂
NH
CH₂
CH₂
2
S Co A
CH₂
NH
NH
Transcribed Image Text:8. The enzyme thiolase catalyzes one step in the ß-oxidation of saturated fats. One portion of the mechanism for this reaction is shown below. Describe the catalytic mechanism at work. (Note: "SCOA" is shorthand for the compound Acetyl-CoA) RCOCH₂COSCoA + HSCOA → H3C₂OSC0A + RCOSCOA HN NH CH₂ NH CH₂ CH₂ FS Grease NH3 H-SCO A NH CH2 CH₂ NH3 S Co A CH₂ NH 1 3 H-SCO A H3C SCO A NH3 a h-SCOA R-C S Co A CH₂ CH₂ C H₂ 0=0 HN NH + NH3 H₂C HN CH₂ NH CH₂ CH₂ 2 S Co A CH₂ NH NH
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