The first-order rate constant, k1, for the decomposition of ampicillin at pH 5.8 and 35?C is k1 = 2 × 10-7 sec-1. The solubility of ampicillin is 1.1 g/100 mL. If it is desired to prepare a suspension of the drug containing 2.5 g/100 mL, calculate the zero-order rate constant, k0, and the shelf-life, that is, the time in days required for the drug to decompose to 90% of its original concentration (at 35?C) in solution. Note: 100 mL = 1 deciliter = 1 dL.
The first-order rate constant, k1, for the decomposition of ampicillin at pH 5.8 and 35?C is k1 = 2 × 10-7 sec-1. The solubility of ampicillin is 1.1 g/100 mL. If it is desired to prepare a suspension of the drug containing 2.5 g/100 mL, calculate the zero-order rate constant, k0, and the shelf-life, that is, the time in days required for the drug to decompose to 90% of its original concentration (at 35?C) in solution. Note: 100 mL = 1 deciliter = 1 dL.
Chemistry by OpenStax (2015-05-04)
1st Edition
ISBN:9781938168390
Author:Klaus Theopold, Richard H Langley, Paul Flowers, William R. Robinson, Mark Blaser
Publisher:Klaus Theopold, Richard H Langley, Paul Flowers, William R. Robinson, Mark Blaser
Chapter12: Kinetics
Section: Chapter Questions
Problem 41E: The reaction of compound A to give compounds C and D was found to be second-order in A . The rate...
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The first-order rate constant, k1, for the decomposition of ampicillin at pH
5.8 and 35?C is k1 = 2 × 10-7 sec-1. The solubility
of ampicillin is 1.1 g/100 mL. If it is desired to prepare
a suspension of the drug containing 2.5 g/100
mL, calculate the zero-order rate constant, k0, and
the shelf-life, that is, the time in days required
for the drug to decompose to 90% of its original
concentration (at 35?C) in solution. Note: 100 mL = 1 deciliter = 1 dL.
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