The following data describe the catalysis of cleavage of peptide bonds in small peptides by the enzyme UTSASE (the arrow indicates the peptide bond cleaved in each case). Substrate Km(mM) kcat(s) PAPAJG 4.0 26 PAPAJA 1.5 37 PAPALF 0.64 18 Based on the above data shown for UTSAse what features of amino acid sequence dictate the specificity of the proteolytic cleavage?

Biochemistry
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Chapter1: Biochemistry: An Evolving Science
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The following data describe the catalysis of cleavage of peptide bonds in small peptides by the enzyme
UTSASE (the arrow indicates the peptide bond cleaved in each case).
Substrate
Km(mM)
kcat(s)
PAPALG
4.0
26
РАPАLA
1.5
37
РАРАLF
0.64
18
Based on the above data shown for UTSAse what features of amino acid sequence dictate the specificity of
the proteolytic cleavage?
A. Large hydrophilic R-groups
B. Large hydrophobic R-groups
C. Neutral R-groups
D. Small hydrophilic R-groups
E. Large hydrophobic R-groups
F. Negatively charged R-groups
G. Positively charged R-groups
Transcribed Image Text:The following data describe the catalysis of cleavage of peptide bonds in small peptides by the enzyme UTSASE (the arrow indicates the peptide bond cleaved in each case). Substrate Km(mM) kcat(s) PAPALG 4.0 26 РАPАLA 1.5 37 РАРАLF 0.64 18 Based on the above data shown for UTSAse what features of amino acid sequence dictate the specificity of the proteolytic cleavage? A. Large hydrophilic R-groups B. Large hydrophobic R-groups C. Neutral R-groups D. Small hydrophilic R-groups E. Large hydrophobic R-groups F. Negatively charged R-groups G. Positively charged R-groups
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