Eukaryotic protein X has one proline residue and two cysteine residues. The proline needs to be in the cis-configuration in the folding protein; and a disulphide bond is formed between the cysteines in the folded protein. Discuss the folding of the protein in solution with protein disulphide isomerase and peptidyl-prolyl isomerase and without these enzymes. Use illustrations to show the differences in the potential folding of protein X under the different conditions.
Eukaryotic protein X has one proline residue and two cysteine residues. The proline needs to be in the cis-configuration in the folding protein; and a disulphide bond is formed between the cysteines in the folded protein. Discuss the folding of the protein in solution with protein disulphide isomerase and peptidyl-prolyl isomerase and without these enzymes. Use illustrations to show the differences in the potential folding of protein X under the different conditions.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Eukaryotic protein X has one proline residue and two cysteine residues. The proline
needs to be in the cis-configuration in the folding protein; and a disulphide bond is
formed between the cysteines in the folded protein. Discuss the folding of the protein in
solution with protein disulphide isomerase and peptidyl-prolyl isomerase and without
these enzymes. Use illustrations to show the differences in the potential folding of
protein X under the different conditions.
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