Answered: The human genes that convey a…

The human genes that convey a susceptibility to hereditary nonpolyposis colorectal cancer are genes coding proteins involved in which DNA repair mechanism?

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter12: Genes And Cancer

Section: Chapter Questions

Problem 13QP: The search for the BRCA1 breast cancer gene discussed in this chapter was widely publicized in the...

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The human genes that convey a susceptibility to hereditary nonpolyposis colorectal cancer are
genes coding proteins involved in which DNA repair mechanism?

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A subset of colorectal cancers is associated with mutations in the Mut genes which code for proteins involved in repairing DNA mismatches. How would mutations in the Mut genes affect the DNA of an individual?
Hereditary nonpolyposis colon cancer (HNPCC) is caused by mutations in proteins from one of the DNA repair pathways. Which pathway is it and what are the protein activities occuring in the pathway?
Describe how mutations in genome maintenance factors promote tumorigenesis. Why would inactivation of a mis- match repair gene cause colon cancer?
Describe the role of mismatch repair (MMR) in DNA repair. Why can mutations in MMR increase the risk of human cancer?
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Describe the role of mismatch repair (MMR) in DNA repair.Why do mutations in MMR proteins increase the risk ofhuman cancer?
MSH2 is a gene commonly associated with HNPCC (Hereditary nonpolyposis colorectal cancer). This gene encodes a protein that is involved in mismatch repair. Why are individuals who are heterozygous for the deletion mutation of MSH2 gene (MSH2+/MSH2-) from birth are very likely to develop colon cancer very early in their lives?
True/False: When first discovered, investigators found it surprising that some single-gene defects causing immunodeficiency syndromes were associated with hypersensitivities to ionizing radiation, thereby leading to increased rates of cancer. The genes accounting for this dual impairment encode ubiquitously expressed DNA repair proteins.
You are evaluating a patient with Nonpolyposis colorectal cancer and his biopsy pathology report reveals a defect in some TSGs involved in DNA mismatch repair, which of these genes is least likely to be implicated in this patients cancer? Group of answer choices SMAD4 MSH2 MLH1 PMS1
There are three broad categories of cancer-related genes: proto-oncogenes, tumor suppressor genes, and DNA repair/stability genes. Distinguish between these three groups, then indicate which you think RB1 belongs to.
BRCA1 is mutated in a large percentage of hereditary breast and ovarian cancers. BRCA1 protein serves as a key enzyme in repairing DNA double-strand breaks. More than 800 mutations in the BRCA1 are clinically significant. This collection of mutations include missense mutations, small deletions, and large rearrangements that result in a protein with reduced function or no protein product. BRCA1 functions by interacting with a variety of proteins, such as Rb, Myc, cyclin-dependent kinase (CDK), and Rad50/51. Rb is important for cell cycle arrest; Myc is a transcription factor that activates genes required for cell proliferation; activated CDK promotes cell cycle progression; and Rad50/51 proteins facilitate repair of DNA double-strand breaks. How many of the mutations listed below would lead to excessive cell growth when the cell was either homozygous or heterozygous for the mutation? Increased expression of Myc Constitutively active Rad50/51 A null mutation in Rb Continuous production…