The manganese ion in the center is attached to 1aspartate ligand, 1 cysteine ligand, and 2histidine ligands. The glutamate residue on thebottom is hydrogen bonded to the histidine sidechain. The pKa of the water that is attached ontop is 7.Part a) If the cysteine ligand was changed to ahistidine ligand, how would the pka of the waterchange? Explain.Part b) If the glutamate residue was changed toleucine, how would the pka of the water change?Explain.OHzHis

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The manganese ion in the center is attached to aspartate ligand, 1 cysteine ligand, and 2 istidine ligands. The glutamate residue on the pottom is hydrogen bonded to the histidine side chain. The pKa of the water that is attached on on is 7

The manganese ion in the center is attached to aspartate ligand, 1 cysteine ligand, and 2 istidine ligands. The glutamate residue on the pottom is hydrogen bonded to the histidine side chain. The pKa of the water that is attached on on is 7

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter3: Stereoisomerism And Chirality

Section3.8: The Significance Of Chirality In The Biological World

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Question

The manganese ion in the center is attached to 1
aspartate ligand, 1 cysteine ligand, and 2
histidine ligands. The glutamate residue on the
bottom is hydrogen bonded to the histidine side
chain. The pKa of the water that is attached on
top is 7.
Part a) If the cysteine ligand was changed to a
histidine ligand, how would the pka of the water
change? Explain.
Part b) If the glutamate residue was changed to
leucine, how would the pka of the water change?
Explain.
OHz
His

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