The skeletal structures of the two amino acids, glycine and lysine, are given below along with the values of the relevant acid dissociation constants (pKa). NH,* pK, - 10.79 - HạN*CH2CO,¯ pK,=9.78 (CH2)4 pK,=2.35 - H,N*ĊHCO,- lysine (Lys) glycine (Gly) pK, - 9.18 pK, - 2.16 For an aqueous solution of glycine alone, calculate the value of pH at which the ratio of the concentration of neutral glycine zwitterions to the concentration of protonated cation is 102.
The skeletal structures of the two amino acids, glycine and lysine, are given below along with the values of the relevant acid dissociation constants (pKa). NH,* pK, - 10.79 - HạN*CH2CO,¯ pK,=9.78 (CH2)4 pK,=2.35 - H,N*ĊHCO,- lysine (Lys) glycine (Gly) pK, - 9.18 pK, - 2.16 For an aqueous solution of glycine alone, calculate the value of pH at which the ratio of the concentration of neutral glycine zwitterions to the concentration of protonated cation is 102.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
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Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Transcribed Image Text:The skeletal structures of the two amino acids, glycine and lysine, are given below along with the values of the
relevant acid dissociation constants (pKa).
NH,* PK, - 10.79
- HạN*CH2CO,¯ S
pK¸=2.35
(CH2)4
- H3N*CHCO,-
pK,=9,78
lysine (Lys)
glycine (Gly)
pK, = 9.18
pK, - 2.16
For an aqueous solution of glycine alone, calculate the value of pH at which the ratio of the concentration of
neutral glycine zwitterions to the concentration of protonated cation is 102.
On your
under each of the following conditions. In the blank, provide the total charge of the dipeptide. (Example: If the
charge is two plus write the answer simply as 2, if the charge is negative two write the answer as -2).
draw the skeletal structure of the dipeptide, Lys-Gly, when it is solvated in an aque
us solution
i. pH= 1
ii. pH= 12
Transcribed Image Text:ii. pH= 12
iii. pH= pl
Calculate the value of pl of the dipeptide, Lys-Gly, assuming that there is negligible shift in the values of acid
dissociation constants from the values of the constituent amino acids.
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