The total amount excreted into urine as unchanged drug after an oral tablet (A) of 50 mg was 36.4 mg. After an oral capsule dose (B) of 25 mg the U" was 20.3 mg. Calculate the relative bioavailability of the tablet A with respect to capsule B. If the absolute bioavailability of the oral capsule is determined to be 0.86 calculate the absolute bioavailability of the tablet dosage form. You are required to list the given data, formula and steps for calculations 5.1
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- A 60-year-old woman who weighs 75kg requires a loading dose of an antibiotic to treat an infection. A plasma concentration of 4.5 mg/L of the antibiotic needs to be achieved for optimal therapeutic effectiveness. The volume of distribution (Vd) of this antibiotic is 0.2 L/kg. The salt factor (S) is 0.6 and bioavailability fraction (F) is 1. The antibiotic is available as a 100 mg/mL infusion.Loading dose = Amount of drug in the bodyBioavailability (F) x Salt fraction (S)Amount of drug in the body = Target conc. (C) x Volume of distribution (Vd)How many millilitres of antibiotic infusion need to be administered?State your answer to 1 decimal place.unit- mlA patient has a deep vein thrombosis (DVT) and needs to be given tinzaparin at a dose of 175units/kg. The patient weights 68 kg. What dose does he need? The strengh(concentration) of tinzaparin available is 20000 units/mL. How many mL should the patient receive?(show work)Downvoted for wrong solution. A river is carrying water containing 2000 mg/l Magnesium Chloride into a small lake. The lake has a naturally occurring Magnesium Chloride of 50 mg/l. If the river flow is 2500 Lmin and the lake flow rate is 1.5 m³.sec¹, what is the concentration of MgCl2 in the lake after the discharge point? Assume that the flows in the river and lake are completely mixed, that the salt is a conservative substance, and the system is at steady state.
- 125.1 mg of streptomycin sulphate are dissolved in 10 ml of water. A GC headspace analysis is carried out in order to determine the methanol content of the drug. A peak for methanol is produced which has 73.2% of the area of a peak for a methanol standard containing 0.532 mg/100 ml of methanol in water analysed under exactly the same conditions, What is the methanol content of the streptomycin sulphate in ppm and %w/w? Answer: 311.3 ppm, 0.3113 % w/w.how??How would you prepare 75 mL of an H2SO4 solution at 20% in weight (density=1.1394 g/mL, richness=227.9 g/L) starting from the commercial H2SO4 solution (98%, density=1.8361 g/mL, richness=1799 g/L)? Please choose among the most appropriate procedure which better describes the preparation of the previous diluted H2SO4 solution: Select one or more: a. Take the required volume of commercial H2SO4 solution with an adequate pipette, pour it into a graduated flask and add water up to the final volume (75 mL in this case). Homogenize the flask by stirring it gently. b. Take a beaker and put about 40 mL of distilled water. Then take the required volume of commercial H2SO4 solution with an adequate pipette and pour them over the beaker. Let the solution be warm and pour the mixture into a graduated flask and add water up to the final volume (75 mL in this case). Homogenize the flask by stirring it gently. c. Take a beaker and put about 40 mL of distilled water. Then take the required volume…What volume (mL) of the prepared low alcoholic elixir is needed if the prescription requires 120 mL of an alcoholic elixir with 35% v/v alcoholic strength? Low alcoholic elixir alcoholic strength: 20% Low Alcoholic ElixirCompound Orange Spirit 10mLAlcohol 100mLGlycerin 200mLSucrose 320gPurified water, qs ad 1000mL High alcoholic elixir alcoholic strength: 79% High Alcoholic ElixirCompound Orange Spirit 4mLSaccharin 3gGlycerin 200mLAlcohol, qs ad 1000mL a 30.51 mL b 119.39 mL c 89.49 mL d 30.61 mL
- 1. AST ELIN nasal spray contains 0.1% azelastine hydrochloride and 125 mcg/mL of benzalkonium chloride as a preservative. A container is capable of delivering 200 metered sprays of 0.137 mL each. Calculate the quantity, in micrograms, of azelastine hydrochloride in each spray.Calculate the ratio strength of benzalkonium chloride in the preparation. Answer #1 = ___ mcg Answer #2 = ___ Please show solution. thank you.You are presented with the following prescription: Rx Drug Y 175 mg Witepsol H15 q.s. Supply 6 suppositories (using 3 g nominal moulds) When using Witepsol H15, moulds will hold 1.06 times their nominal weight. The displacement value of Drug Y in Witepsol H15 is 1.1. Calculate the mass of Witepsol H15 required to prepare this product. Give your answer to two decimal placesLouie performed paper chromatography to identify which among the four availablereference mixtures — WAR, OFF, YIN, MEW — have the same components as hisunknown sample, GUN. He spotted the standards and the sample in a Whatman No. 1filter paper, which he placed in a developing chamber containing 3% KCl. After 20minutes, Louie obtained the chromatogram below, immediately noting that the distancetravelled by the solvent from the origin is 79.0 mm. On the other hand, the distances (incm) traveled by the developed spots were tabulated as follows.(see attached) Questions: 1. Is the type of paper chromatography performed normal or reversed? Why?2. Calculate the Rf of the spots from the samples. Report your answers in four decimal places.
- The gravimetric factor used to express CoCBr6·H20 in a sample that is finally weighed as PbClBr is choose below: FW PbClBr / 6 x FW CoCBr6·H20 FW CoCBr6·H20 / FW PbClBr FW CoCBr6·H20 / 6 x FW PbClBr 6 x FW PbClBr / FW CoCBr6·H202.3-3 Calculate the Ksp of the following aqueous solutions: a) 3.60x10-5M Ag2CO3 b) 4.30x10-3M of Ag+ in Ag2C2O4 solution c) 4.80 mol of PbCrO4 dissolved in 2.00 L container.What volume (in mL) of the prepared high alcoholic elixir is needed if Rx requires 120 mL of an alcoholic elixir with 35% v/v alcoholic strength? Low alcoholic elixir alcoholic strength: 20% High alcoholic elixir alcoholic strength: 79% a 30.51 mL b 89.49 mL c 34.80 mL d 85.20 mL