What is the result of histone tal deacetylation on histone-DNA interaction?Increase in positive charge to histone leads to tighter interactionsO Addition of positive charge to histone repels DNA and loosens interactionO No effect, as the histone tail does not interact with DNAO Neutralisation of charge on histone loosens interaction with DNAO Neutralisation of charge on histone leads to tighter interaction with DNA

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Answered: What is the result of histone tail…

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter29: Transcription And The Regulation Of Gene Expression

Section: Chapter Questions

Problem 9P

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True or False 1. Histone proteins are able to associate with DNA segments because of the anionic nature of the amino acids arg and lys. 2. DNA molecules can perform their function in replication and transcription as long as the hydrogen bonds between the bases remain intact. 3. A double helix makes one complete turn every 10 residues (3.4nm). Therefore the distance between base pairs is 0.34nm.
Which of these is NOT true of nucleosomes? A. Some post-translational modifications to histone proteins serve as binding sites for transcription factors. B. The position of nucleosomes is fixed on the genome and can not be changed. C. The position and post-translational modifications of histones can be inherited through mitosis. D. The binding between DNA and histone proteins can be disrupted by post-translational modifications.
Amino acid sequences from a cell cycle control protein from a patient with cancer and a healthy person are aligned. The sequence from the cancer patient indicates one amino acid has changed from phenylalanine (Phe) to leucine (Leu). A mutation in the cancer patient's DNA must have taken place. Identify the result of this DNA change in the mRNA codon that led to this change in the protein sequence. Use the codon table to help you. UUU altered to UUA CAA altered to UUU UUU altered to UAU
Fill in the blank The ______ acts to position RNA polymerase II for transcription initiation. The enzyme _________ is important or releasing torsional stress during DNA replication ____________ of histone tails will neutralize their DNA binding resulting in decondensation of the chromatin.
The activity of ________ will result in an increasedpositive charge on the histone. Question 24 options: Histone acetyltransferase Histone deacetylase Histone methyltransferase Maintenance methylase Histone demethylase
The amino acid sequence of part of a protein has beendetermined:N . . . Gly Ala Pro Arg Lys . . . CA mutation has been induced in the gene encodingthis protein using the mutagen proflavin. The resultingutant protein can be purified and its amino acidsequence determined. The amino acid sequence of themutant protein is exactly the same as the amino acidsequence of the wild-type protein from the N terminus of the protein to the glycine in the preceding sequence. Starting with this glycine, the sequence ofamino acids is changed to the following:N . . . Gly His Gln Gly Lys . . . CUsing the amino acid sequences, one can determinethe sequence of 14 nucleotides from the wild-typegene encoding this protein. What is this sequence?
Figure 28.41 gives some examples of recombination in IgG codons 95 and 96, as specified by the Vkand Jkgenes. List the codon possibilities and the amino acids encoded if recombination occurred in codon 97. Which of these possibilities is less desirable?
Histones are: Group of answer choices Are present in eukaryotic, but not prokaryotic chromosomes All of these are true Have tails that can be modified and thereby change how actively a gene is transcribed Generally positively charged Are the protein components of nucleosomes
Cancer cells removed from a patient's tumor have increased gene expression of several hundred genes (including many cancer-causing genes). Scientists determine that the histones from the cancer cells have an overall/average lower affinity for DNA than histones from normal control cells. Which drug is most likely to help treat this patient's cancer? a. An inhibitor for HMT (histone methyltransferases) b. An inhibitor for HDM (histone demethylases) c. An inhibitor for HDACs (histone deacetylases) d. An inhibitor for HATs (histone acetyltransferase)
Incorrect statement about m-RNAa) Cap is added to the 5’ endb) Introns are removed and exons are spliced togetherc) Histone mRNAs lack 5’ capd) Poly-A tail is added to the 3’ end
Give at least one example of a chromosomal structureor function affected by the following mechanisms formodulating chromatin structure:a. Posttranslational changes of the normal histonesfound in the nucleosome
I. The retinoic acid receptor (RAR) is a transcription factor that is similar to steroid hormone receptors. Thesubstance (ligand) that binds to this receptor is retinoicacid. One of the genes whose transcription is activatedby retinoic acid binding to the receptor is myoD. Thediagram that follows shows a schematic view of theRAR proteins produced by genes into which one oftwo different 12-base double-stranded oligonucleotides had been inserted in the ORF. The insertion site(a–m) associated with each mutant protein is indicatedwith the appropriate letter on the polypeptide map.For constructs encoding proteins a–e, oligonucleotide 1(5′ TTAATTAATTAA 3′ read off either strand) wasinserted into the RAR gene. For constructs encoding proteins f–m, oligonucleotide 2 (5′ CCGGCCGGCCGG 3′)was inserted into the gene.NH2 f g h i j k l m COOHa b c d eThe wild-type RAR protein can both bind DNA and activate transcription weakly in the absence of retinoic acid(RA) and strongly in RA’s presence. Each…

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