16a) The Iron Response Factor (IRF) is an RNA binding protein that recognizes and binds to a specific sequence, known as the Iron Response Element (IRE), when intracellular iron levels are low, but not when intracellular iron levels are high. Briefly explain in general terms what happens as intracellular iron levels increase that causes the IRF protein to lose its capacity for binding to the IRE sequence in RNA.

Biology 2e
2nd Edition
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark
Chapter16: Gene Expression
Section: Chapter Questions
Problem 38CTQ: A scientist discovers a virus encoding a Protein X that degrades a subunit of the elF4F complex....
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16a) The Iron Response Factor (IRF) is an RNA binding protein that recognizes and binds to a specific
sequence, known as the Iron Response Element (IRE), when intracellular iron levels are low, but not
when intracellular iron levels are high. Briefly explain in general terms what happens as intracellular
iron levels increase that causes the IRF protein to lose its capacity for binding to the IRE sequence in
RNA.
Transcribed Image Text:16a) The Iron Response Factor (IRF) is an RNA binding protein that recognizes and binds to a specific sequence, known as the Iron Response Element (IRE), when intracellular iron levels are low, but not when intracellular iron levels are high. Briefly explain in general terms what happens as intracellular iron levels increase that causes the IRF protein to lose its capacity for binding to the IRE sequence in RNA.
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