Which of the following statements are correct about protein folding (select all that appy)?   A. Protein folding is a very slow process with most proteins requiring >30 min to go from unfolded to native conformation   B. The mature two-chain form of insulin spontaneously folds into the native conformation   C. A sharp transition in the presence of denaturants (See Figue 8.1) suggests the protein folds without intermediates   D. Proteins randomly sample each possible conformation before arriving final native state   E. Proteins with disulfide bridges tend not follow a simple two-state folding mechanism.

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Osmosis

In simple words, osmosis is the slow, gradual movement of a liquid through a membrane. But there are nuances to this process. For instance, there has to be an imbalance in the distribution of solute in the liquid on either side of the membrane, which has to be semipermeable. The liquid in the region with a lower solute concentration moves to the region with a higher concentration, thereby displacing the solution in the process. The objective is to equalize the concentration of molecules on both sides of the membrane; the displacement of liquid can be viewed as a byproduct of this equalization. Since there is no energy required to carry osmosis, it is considered a passive process.