Which of the following statements is NOT true of tyrosine kinase-linked receptors? Select one a Monomeric receptors are often induced to dimerize upon ligand binding b. The cytoplasmic side of the receptor contains a kinase enzyme domain that is activated upon ligand binding c. The activated receptors attract and activate G proteins to continue the signal pathway

Which of the following statements is NOT true of tyrosine kinase-linked receptors? Select one a Monomeric receptors are often induced to dimerize upon ligand binding b. The cytoplasmic side of the receptor contains a kinase enzyme domain that is activated upon ligand binding c. The activated receptors attract and activate G proteins to continue the signal pathway

Biology: The Dynamic Science (MindTap Course List)

4th Edition

ISBN:9781305389892

Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Chapter39: Information Flow And The Neuron

Section: Chapter Questions

Problem 1ITD: You learned in this chapter that Na+/K+ active transport pumps in the plasma membrane of the axons...

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You learned in this chapter that Na+/K+ active transport pumps in the plasma membrane of the axons are responsible for creating the imbalance between Na+ and K+ inside and outside of the neuron that produces the resting membrane potential. In early research studying the role of ions and the involvement of active transport of ions in neural signaling, investigators used the giant axon of a squid as a model. The diameter of a giant axon is far greater than that of a mammalian axon, which enabled researchers to isolate it easily and use it in in vitro experiments. In one early experiment, researchers investigated the active transport of Na+ out of the axon in response to the presence of cyanide. Experimentally they hooked up a section of axon to a syringe, immersed the axon in artificial seawater, introduced radioactive 22Na (as 22NaCl) into the axon, and then quantified the transport of 22Na out through the axons plasma membrane. The rate of 22Na transport out of the axon was determined by measuring the radioactivity released into the fluid sur- rounding the axon over a period of time. The Figure shows the results of the experiment. What is the effect of cyanide on Na1 transport out of the squid axon? How do the data show the effect? Source: P. C. Caldwell et al. 1960. The effects of injecting energy-rich phosphate compounds on the active transport of ions in the giant axons of Loligo. The Journal of Physiology 152:561590. Cengage Learning 2017
Which of the following would inhibit the activity of TGF-Beta receptor? multiple answers A. Deletion of Extracellular domain B. Tyrosine Kinase Inhibitor C. Mutation that prevents homodimerization of Type II Receptor D. Mutation of phosphorylation site on Type I receptor E. Inhibition Type II receptor binding to Type I receptor
In which condition is Protein A kinase activated? #1B-arrestin is always active. #2 Lack of kinase domain in BARK #3 ß1-adrenergic membrane receptor lacking it's ligand-binding domain
An extracellular signaling molecule binds to cell surface receptor. This cell surface receptor changes shape and activates a trimeric G-protein. What kind of receptor is this? a) Ion-channel coupled receptor b) Receptor Tyrosine Kinase c) G-Protein coupled receptor d) All of the other answers are correct e) Enzyme-coupled receptor
Which of the following statements most accurately describes what happens when an antagonist binds to a receptor? The antagonist binds non-covalently to the receptor and promotes internalisation of the receptor. Antagonist binding alters the structure of the receptor making it unable to function normally. At sufficiently high concentrations the antagonist can prevent the receptor from binding to its natural (endogenous) ligand. The antagonist-receptor complex binds to a heterotrimeric G protein forming a stable and inactive ternary complex.
Which of the following is true of signal transduction mediated by protein tyrosine kinases production of cAMP phosphoinositides are activated arrestins compete with G-proteins phosphorylation of tyrosine residues
A drug binds to a receptor and causes an immediate change in the electrical signaling or excitability of that cell, without activating another signaling molecule. What type of receptor is this drug most likely binding to? G-protein coupled receptor (GPCR) Ligand-gated ion channel Enzyme-coupled receptor Intracellular receptor Voltage-gated ion channel
A particular protein can bind to receptor tyrosine kinase molecules inhibiting their dimerization (stops them from being able to form dimers). Explain what effect you think this protein could have on the signal transduction pathways that use tyrosine kinase as a receptor if it were to be present in a cell.
What do steroid hormone signaling and receptor tyrosine kinase (RTK) signaling have in common? Their pathways involve G-proteins that are activated by GDP-GTP exchange. They both result in gene transcription. They both use the second messenger cAMP. The receptors are both enzymes.
The major function of cAMP in animal cells is to activate adenylyl cyclase protein kinase A protein kinase C tyrosine kinases
Which of the following statements best defines the term ‘spare receptors’? ‘Spare receptors’ refers to receptors that are broken down by cells because they are surplus to requirements. ‘Spare receptors’ occur when the KD for agonist binding to the receptor is smaller than the EC50 determined for a particular physiological response. ‘Spare receptors’ refers to the pool of intracellular receptors that are able to translocate to the plasma membrane. ‘Spare receptors’ can be defined as the number of receptors not occupied by agonist when a maximal response has been achieved, compared to the total number of receptors in the cell.
Nerve growth factor binds to which type of receptor? a.) Receptor tyrosine phosphatases b.) Receptor Serine/Threonine Kinase c.) Receptor guanylyl cyclase d.) Receptor tyrosine kinase