Which THREE statements are true about targetting proteins to the nudieus?Aln the cytoplasm, a protein with an appropriate nuclear localization signal (NLS)is brund by a compna sd mointImportins a and B and CAS are degraded in the nucieusThe nuclear localization sequence usually contains around 20 ameno aoidsThe nuclear localization sequence contains severai consecutive basic (Arg or Lysi meThe nuclear localization sequence is ocated almost anywhere in protein amino aad sequerceThe nuclear localization sequence is emoved after targeting to the nucleus

Nuclear localization signals mediates the transport of proteins from the cytoplasm into the nucleus.

Answered: Which THREE statements are true about…

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter29: Transcription And The Regulation Of Gene Expression

Section: Chapter Questions

Problem 13P

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What is the role of the Ran-GEF protein in nuclear transport? Ran-GEF converts RanGTP to RanGDP Ran-GEF binds Ran-GAP on inside of nucleus to speed up transport Ran-GEF converts RanGDP to RanGTP Ran-GEF maintains the RanGTP concentration on the inside of the nucleus low Ran-GEF binds directly to the nuclear pore to facilitate transport
What would most likely occur to nuclear-cytoplasmic shuttling if the intrinsic GTPase activity of RAN was slowed down by 50%? Group of answer choices RAN would not bind exportin and proteins would accumulate in the nucleus All of the answers are likely None of the answers are likely Importin beta would not release from RAN in the cytoplasm and nuclear import would slow down RAN would not bind to importin beta and protein cargo in the nucleus would not release
Early researchers experimented with nucleoplasmin and demonstrated that proteins targeted to the nucleus have a specific nuclear localization sequence. Remembering this experiment, which of the following statements is true? a. The core nucleoplasmin fragment ended up in the nucleus. b. nucleoplasmin does not require a nuclear localization sequence to enter the nucleus c. The tail nucleoplasmin fragment has the nuclear localization sequence d. Nuceloplasmin was fragmented and the parts were injected into the same cell
Maintaining nuclear RanGTP levels is critical for nucleo-cytoplasmic transport. Describe how mutations that disrupt RanGEF function would affect the movement of proteins coming in and going out of the nucleus.
Match the primary sequence to its characteristics/function/fate N-signal signal-anchor stop-anchor nuclear localization sequence KDEL 1. found at carboxyl terminus of ER resident proteins, interaction with its receptor directs retrieval from Golgi 2. hydrophobic, interacts with SRP and translocon, becomes transmembrane helix 3. mostly hydrophobic, interacts with SRP, cut off 4. hydrophobic, interacts with translocon, becomes transmembrane helix 5. basic, interacts with importin-alpha
Which of the following statements is true? Question 9 options: a) Executioner caspases are activated by cleavage. b) Initiator caspases are activated by cleavage. c) Executioner caspases are activated by dimerization. d) Executioner caspases trigger apoptosis but initiator caspases does not.
during anaphase of animal cells, describe the appearance of the DNA, spindle fibers and location of the chromosomes pls do not copy from google
Determine how many domains and list the residues in each domains (ei. 1-230, 1-120) Vertebrate Ca 2+ -dependent cell adhesion protein (4VCA): Proteobacterial DNA topoisomerase subunit (5PDT): Vertebrate cell receptor (6VCR)
Fill in the blank: Polymorphonuclear leukocyte is another name for a _______________________ with a segmented nucleus.
The cisternal space of ER is continuous with prenuclear space between the two membranes of the nuclear envelope and can communicate with the internals spaces of the Golgi complex and lysosome by means of _____________ that shuttle between these structures. Which of the following experimental observations would suggest that chromosomes move by polymerization of tubulin subunits?
The separation of the parent cell into two daughter cells fails to occur during the process of binary fission. Based on your knowledge of cell constriction in bacteria, what protein may be missing in the system (i.e the protein was not expressed)?
Chromatin is differentiated into heterochromatin and euchromatin regions, on the basis of staining behaviour in a typical nucleus. Which of the given statements is/are correct w.r.t. heterochromatin? (A) Lightly stained region (B) Chromatin is densely packed (C) Transcriptionally it is inactive (D) Darkly stained region 1. (A) only 2. (A) and (C) only 3. (A), (B) and (C) 4. (B), (C) and (D)

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