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You discover a new gene cluster from a strain of the bacterium Streptomyces. The domains of the four-module mixed NRPS/PKS assembly line are shown below, along with relevant starting material: Module 1 Domains 3 4 A, PCP AT, ACP, KS, KR AT, ACP, KS, KR, DH, ER Methyl Malonyl CoA А, РСР, С, Е, MT, ТЕ Val Substrate Editing domains: KR = beta-keto-reductase; DH = dehydratase; ER = enoyl reductase; MT = methyl transferase; E = epimerase Ala Malonyl CoA `S-COA `S-CoA Malonyl CoA Methyl Malonyl CoA Draw the structure of the natural product that would result from the assembly line above if the TE domain functions as a hydrolase. Please only include the stereochemistry for the amino acid side chains.

You discover a new gene cluster from a strain of the bacterium Streptomyces. The domains of the four-module mixed NRPS/PKS assembly line are shown below, along with relevant starting material: Module 1 Domains 3 4 A, PCP AT, ACP, KS, KR AT, ACP, KS, KR, DH, ER Methyl Malonyl CoA А, РСР, С, Е, MT, ТЕ Val Substrate Editing domains: KR = beta-keto-reductase; DH = dehydratase; ER = enoyl reductase; MT = methyl transferase; E = epimerase Ala Malonyl CoA `S-COA `S-CoA Malonyl CoA Methyl Malonyl CoA Draw the structure of the natural product that would result from the assembly line above if the TE domain functions as a hydrolase. Please only include the stereochemistry for the amino acid side chains.

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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You discover a new gene cluster from a strain of the bacterium Streptomyces. The domains of the four-module mixed NRPS/PKS assembly line are shown below, along with relevant starting material: Module 1 3 4 А, РСР, С, Е, МТ, ТЕ Val Domains А, РСP | АT, АСР, KS, KR AT, ACP, KS, KR, DH, ER Methyl Malonyl CoA Malonyl CoA Substrate Editing domains: KR = beta-keto-reductase; DH = dehydratase; ER = enoyl reductase; MT = methyl transferase; E = epimerase Ala %3D S-COA S-COA Malonyl CoA Methyl Malonyl CoA Draw the structure of the natural product that would result from the assembly line above if the TE domain functions as a hydrolase. Please only include the stereochemistry for the amino acid side chains.
Transcribed Image Text:You discover a new gene cluster from a strain of the bacterium Streptomyces. The domains of the four-module mixed NRPS/PKS assembly line are shown below, along with relevant starting material: Module 1 3 4 А, РСР, С, Е, МТ, ТЕ Val Domains А, РСP | АT, АСР, KS, KR AT, ACP, KS, KR, DH, ER Methyl Malonyl CoA Malonyl CoA Substrate Editing domains: KR = beta-keto-reductase; DH = dehydratase; ER = enoyl reductase; MT = methyl transferase; E = epimerase Ala %3D S-COA S-COA Malonyl CoA Methyl Malonyl CoA Draw the structure of the natural product that would result from the assembly line above if the TE domain functions as a hydrolase. Please only include the stereochemistry for the amino acid side chains.
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