BIOLOGY (LL)
5th Edition
ISBN: 9781264115495
Author: BROOKER
Publisher: MCG
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Chapter 1, Problem 2COQ
Summary Introduction
To explain: The way in which the given phenomenon is related to genomes and proteomes.
Introduction: Genome is defined as the complete genetic material that is present in an organism. It consists of both the coding as well as the non-coding parts of DNA. The study of the genome is termed as genomics. Whereas, the complete set of proteins that an organism consists is known as proteome. Proteomics is the study of proteome on a larger scale.
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Another way to study the role of proteins (e.g., transcription factors) that function in development is to microinject the mRNA that encodes a protein, or the purified protein itself, into an oocyte or embryo, and then determine how this affects the subsequent development of the embryo, larva, and adult. For example, if Bicoid protein is injected into the posterior region of an oocyte, the resulting embryo will develop into a larva that has anterior structures at both ends. Based on your understanding of the function of each developmental gene, what would be the predicted phenotype if the following proteins or mRNAs were injected into normal oocytes?
A. Nanos mRNA injected into the anterior end of an oocyte
B. Antp protein injected into the posterior end of an embryo
C. Toll mRNA injected into the dorsal side of an early embryo
Dystrophin is a protein that forms part of a vital protein complex that connects the cytoskeleton of a muscle fiber cell to the extracellular matrix. This connection strengthens and shapes the muscle fibers.
Dystrophin is coded by the DMD gene. This is one of the longest human genes known, covering 2,300,000 base pairs (0.08% of the human genome) It is located in chromosome 21. The immature mRNA is 2,100,000 bases long and takes 16 hours to transcribe. It contains 79 exons. The mature mRNA measures 14,000 and codes for a protein with 3,685 amino acids.
Abnormal expression of dystrophin leads to severe symptoms like muscle weakness and fatigability, a disease that is called muscular dystrophy. Most patients with muscular dystrophy become wheelchair dependent early in life. Cardiac muscle is also affected which results typically in premature death (~ second or third decade of life). Several mutations in this gene have led to the production of low levels of dystrophin or of a defective,…
“In an organism that reproduces asexually, there is no difference between a somatic cell mutation and a germ line mutation.” Is this statement true? Explain.
Chapter 1 Solutions
BIOLOGY (LL)
Ch. 1.1 - At which level of biological organization would...Ch. 1.3 - What is the relationship between biological...Ch. 1.3 - How does the concept of a tree of life differ from...Ch. 1.3 - Biologists sometimes say that the genome is the...Ch. 1.4 - Figure 1.10 The three domains of life. Two of...Ch. 1.4 - Why is it useful to place organisms into taxonomic...Ch. 1.5 - What is the purpose of a control group in...Ch. 1.5 - Explain how discovery-based science helped...Ch. 1.6 - Discuss the difference between discovery-based...Ch. 1.6 - What are the steps in the scientific method, also...
Ch. 1.6 - Prob. 3EQCh. 1.6 - Prob. 1CSCh. 1.6 - Core Skill: Modeling This modeling challenge asks...Ch. 1 - Which of the following is not a core concept of...Ch. 1 - Populations of organisms change over the course of...Ch. 1 - Prob. 3TYCh. 1 - Which of the following is an example of horizontal...Ch. 1 - The scientific name for humans is Homo sapiens....Ch. 1 - The complete genetic makeup of an organism a....Ch. 1 - Prob. 7TYCh. 1 - Prob. 8TYCh. 1 - Prob. 9TYCh. 1 - What is the purpose of using a control group in a...Ch. 1 - Of the five core concepts of biology described in...Ch. 1 - Explain how it is possible for evolution to result...Ch. 1 - Prob. 3CQCh. 1 - Discuss whether or not you think that theories in...Ch. 1 - Prob. 2COQ
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- A pharmaceutical researcher performs preclinical testing on a novel chemotherapeutic drug. When rat embryos are exposed to this drug during an early stage of organogenesis, they develop severe skeletal malformations. Further genetic analysis reveals that the drug causes mutations in numerous homeobox genes containing highly conserved 180 base pair DNA sequences. The genes affected by this drug most likely code for which of the following proteins?arrow_forwardWhich one of the following statements about nucleosomes is false? a) The DNA double helix wraps around the nucleosome. b) The sequence of amino acid in a histone tail is altered during chromatin remodeling. c) A nucleosome is composed of 8 histone proteins; two copies of each type of histone. d) A large percent of the nucleosome is positively charged.arrow_forwardWhat is the result when the core histones are acetylated via histone acetyltransferase? A) The result depends on which histone is modified. B) The DNA becomes more tightly associated with the core. O C) The DNA becomes less associated with the core. This modification has no effect on how tightly associated DNA will become with the core.arrow_forward
- How many copies of each type of core histone would it take to wrap the entire human genome into nucleosomes? How has evolution solved the problem of producing such a large number of proteins in a relatively short period of time?arrow_forwardYou engineer a chromosomally XY mouse in which SRY gene is inactivated. What do you expect to observe in this mouse? a) the mouse will develop male anatomical feautures b) the mouse will develop female anatomical feautures c)the mouse Y chromosome will convert into an X chromosome d) the mouse X chromosome will convert into a Y chromosome e) the mouse will exhibit an additional X chromosome making it XXYarrow_forwardIn a human karyotype, chromosomes are arranged in 23 pairs. If one of the autosomal pairs is examined, which of the following characteristics will the two chromosomes of the pair have in common? a) loci and staining pattern b) length and DNA sequence c) X-like shape and alignment on the metaphase plate d) alleles and centromere positionarrow_forward
- Describe experimental evidence that would indicate that most or nearly all of the DNA sequences in a mammalian genome are transcribed.arrow_forwardThe phenotype of a heterozygous mouse (Aa) is agouti. The agouti banding pattern is due to altered expression of the agouti gene. Which of the following statement is false? a) Expression of the agouti gene inhibits the production of eumelanin. b) Evidence suggests that the agouti gene is only expressed in tissues associated with fur production. c) Epigenetic markers silence the agouti gene resulting in dark pigmentation at the tip and root of the hair. d) All of the abovearrow_forwardList reasons why the proteome is larger than the genome.arrow_forward
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