BIOLOGY:CONCEPTS+INVEST.-CONNECT ACCESS
5th Edition
ISBN: 9781260542233
Author: Hoefnagels
Publisher: MCG
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Chapter 10, Problem 9MCQ
Summary Introduction
Introduction:
The female carries two X chromosomes whereas male carry one X chromosome. Thus, the presence of two X chromosomes result in the formation of double amount of protein associated with protein which may result in disease. Thus, the inactivation of one X chromosome in female is necessary. This phenomena is known as dosage compensation.
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You are interested in the expression of regions of the X chromosome at different times in human fetal development. You hypothesize that large regions of the X chromosomes will be expressed at times when parts of the reproductive organs are developing. What structural and chemical characteristics of the X chromosome might you look at over time to determine when expression of genes on the X chromosome is enhanced or repressed?
. In humans, hemophilia is an X-linked recessive gene and will only be expressed in females if they are homozygous for this gene. However, in some rare cases, a heterozygote becomes hemophilic. Explain how this incident happens and why will there be skewed X-inactivation?
Which is a FALSE statement about X inactivation in mammalian females?
O Females that are heterozygous for an X-linked gene have patches of cells that express one allele and patches of cells that express the other.
O Xinactivation is random as to which X is inactivated and takes place early in embryonic development
Inactivation is initiated by expression of the Xist gene on the X chromosome that will remain active.
Once an X chromosome first becomes inactivated in a cell, that same X will remain inactivated in somatic cells that are descendants of this cell.
DOOO
Chapter 10 Solutions
BIOLOGY:CONCEPTS+INVEST.-CONNECT ACCESS
Ch. 10.1 - Describe the relationships among chromosomes, DNA,...Ch. 10.1 - Prob. 2MCCh. 10.2 - Why did Gregor Mendel choose pea plants as his...Ch. 10.2 - Distinguish between dominant and recessive;...Ch. 10.2 - Prob. 3MCCh. 10.3 - What is a monohybrid cross, and what are the...Ch. 10.3 - How are Punnett squares helpful in following...Ch. 10.3 - Prob. 3MCCh. 10.3 - How does the law of segregation reflect the events...Ch. 10.4 - Prob. 1MC
Ch. 10.4 - Prob. 2MCCh. 10.4 - How can the product rule be used to predict the...Ch. 10.5 - How do patterns of inheritance differ for unlinked...Ch. 10.5 - What is the difference between recombinant and...Ch. 10.5 - Prob. 3MCCh. 10.6 - Prob. 1MCCh. 10.6 - Differentiate between pleiotropy and epistasis.Ch. 10.6 - How can the same phenotype stem from many...Ch. 10.6 - Figures 10.18 and 10.20 show two ways that a...Ch. 10.7 - Prob. 1MCCh. 10.7 - Prob. 2MCCh. 10.7 - Why do males and females express recessive...Ch. 10.7 - Prob. 4MCCh. 10.8 - Prob. 1MCCh. 10.8 - Prob. 2MCCh. 10.9 - Prob. 1MCCh. 10.9 - Prob. 2MCCh. 10.10 - Prob. 1MCCh. 10.10 - Prob. 2MCCh. 10 - In the list of four terms below, which term is the...Ch. 10 - According to Mendel, if an individual is...Ch. 10 - Prob. 3MCQCh. 10 - Which of the following is a possible gamete for an...Ch. 10 - Use the product rule to determine the chance of...Ch. 10 - Refer to the linkage map in figure 10.16b. A...Ch. 10 - How can epistasis decrease the number of...Ch. 10 - Prob. 8MCQCh. 10 - Prob. 9MCQCh. 10 - Prob. 1WIOCh. 10 - Prob. 2WIOCh. 10 - Some people compare a homologous pair of...Ch. 10 - How did Mendel use evidence from monohybrid and...Ch. 10 - Prob. 5WIOCh. 10 - Prob. 6WIOCh. 10 - Prob. 7WIOCh. 10 - Prob. 8WIOCh. 10 - Prob. 9WIOCh. 10 - A family has an X-linked dominant form of...Ch. 10 - X inactivation explains the large color patches in...Ch. 10 - Prob. 12WIOCh. 10 - Prob. 13WIOCh. 10 - Design an experiment using twins to determine the...Ch. 10 - Prob. 1GPCh. 10 - In Mexican hairless dogs, a dominant allele...Ch. 10 - A species of ornamental fish comes in two colors;...Ch. 10 - Two lizards have green skin and large dewlaps...Ch. 10 - Prob. 5GPCh. 10 - Prob. 6GPCh. 10 - Prob. 7GPCh. 10 - Prob. 8GPCh. 10 - Prob. 9GPCh. 10 - Prob. 1PITCh. 10 - Explain the effects of a mutation, using allele,...Ch. 10 - 3. Add meiosis, gametes, incomplete dominance,...
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- In marsupials, X inactivation occurs exclusively to paternally derived chromosomes. Which genes will ALWAYS be expressed in this situation? A. maternal X-linked genes B. paternal X-linked genes C. maternal Y-linked genes D. paternal Y-linked genesarrow_forwardFor XCI to occur, where are the Xist and Tsix genes expressed?a. Xist is expressed only on Xa, and Tsix is expressed onlyon Xi.b. Xist is expressed only on Xi, and Tsix is expressed onlyon Xa.c. Xist is expressed only on Xa, and Tsix is expressed onlyon Xa.d. Xist is expressed only on Xi, and Tsix is expressed onlyon Xi.arrow_forwardFor the Igf2 gene, where do de novo methylation and maintenancemethylation occur?a. De novo methylation occurs in sperm, and maintenancemethylation occurs in egg cells.b. De novo methylation occurs in egg cells, and maintenancemethylation occurs in sperm cells.c. De novo methylation occurs in sperm, and maintenancemethylation occurs in somatic cells of offspring.d. De novo methylation occurs in egg cells, and maintenancemethylation occurs in somatic cells of offspring.arrow_forward
- Imagine a scenario in which prenatal testing of a human female fetus indicates that the baby will have a normal XX karyotype but is heterozygous for a mutation that inactivates the Xist promoter. Allele “Xr” represents the mutated version of the Xist promoter, and “XR” represents the normal version of the Xist promoter. How will this mutation affect the process of X inactivation?A. "X inactivation will still be random with both mutant and normal X chromosomes being randomly inactivated" B. "The chromosome with the mutant Xist promoter will always be active" C. "The chromosome with the mutant Xist promoter will always be inactivated" D. "The normal X chromosome (no mutation in Xist) will always be active" E. "The normal X chromosome (no mutation in Xist) will always be inactivated"arrow_forwardFigure 19.25 shows that the Sxl protein binds to the mRNA of the msl-2 gene, inhibiting translation of the mRNA’s proper reading frame. The MSL-2 protein is a transcription factor that binds to the X chromosome in XY males to double the level of X-linked gene transcription, thus equalizing X-linked gene expression in XY males and XX females. a. In which sex, XY males or XX females, would the Sxl protein bind to the msl-2 mRNA? b. As discussed in Problem 35, some Sxl alleles are lethal to females and others are lethal to males. Is the function of Sxl in regulating the synthesis of Msl-2 protein sufficient to explain the sex-specific lethality caused by both kinds of alleles? c. Predict the effect of loss-of-function mutations in msl-2 on male and female fertility and viability.arrow_forwardWhich of the following statements is TRUE? Overexpression of the X-chromosome in the somatic cells of males a. leads to the formation of a Barr body in male cells' nuclei. b. leads to cellular mosaicism in males hemizygous for an X-linked gene. c. is characteristic of all XY systems of sex determination. d. is the mechanism in flies to compensate for the higher dosage of X-linked genes in females as compared to males. e. None of the abovearrow_forward
- Why are dominant mutations in proto-oncogenes generally not inherited? A. Inherited mutations in proto-oncogenes would not affect cell division rate B. Inherited mutations in proto-oncogenes would decrease cell division rate and no viable embryo would form C. Inherited mutations in proto-oncogenes would increase cell division rate and no viable embryo would form D. Dominant mutations in proto-oncogenes are always inheritedarrow_forwardWhich of the following statements is FALSE? Inactivation of one of the two X chromosomes in the somatic cells of mammalian females..... a. underlies the Calico phenotype in cats. b. leads to cellular mosaicism in females heterozygous for an X-linked gene. c. affects 75 % of the paternal and 25 % of the maternal X-chromosomes of a mammalian body. d. leads to the formation of a Barr body in female cells' nuclei. e. is the mechanism in mammals to compensate for the higher dosage of X-linked genes in females as compared to males.arrow_forwardWhich of the following is a FALSE statement? A) An individual with two X chromosomes and one Y chromosome has testes. B. The human female determines the sex of her offspring. (C) Genomic imprinting allows for differential expressions of an allele. D. Epigenetic changes can be passed on to a zygote. Deletion of the SRY gene would cause male fetuses to develop as females.arrow_forward
- Describe the molecular process of X-chromosome inactivation.This description should include the three phases of inactivationand the role of the Xic. Explain what happens to the X chromosomes during embryogenesis, in adult somatic cells, and duringoogenesis.arrow_forwardDescribe the process of X-chromosome inactivation in mammalsarrow_forwardX inactivation explains the large color patches in calico cat fur and the smaller patches in tortoiseshell cat fur. In which type of cat do you expect X inactivation occurs earlier in development? Why?arrow_forward
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