Campbell Essential Biology (6th Edition) - standalone book
6th Edition
ISBN: 9780133917789
Author: Eric J. Simon, Jean L. Dickey, Jane B. Reece, Kelly A. Hogan
Publisher: PEARSON
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Chapter 11, Problem 14PS
The human body has a far greater variety of proteins than genes, highlighting the importance of alternative RNA splicing. Suppose you have samples of two types of adult cells from one person Design an experiment using microarrays to determine whether different gene expression is due to alternative RNA splicing.
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Discuss the advantages, in terms of protein structure and evolution, that result from alternative mRNA splicing.
You are studying a rare form of brain cancer where the newly-discovered genes BR and AIN are known to play a role in the development of this cancer. You perform a RNA-seq analysis on a patient with this form of cancer and compare the resulting expression histogram to a healthy patient. You conclude that AIN is heavily upregulated in the cancer patient and that the cancer patient's mRNA for BR retains one of that gene's introns in the RNA-seq results. Based on this information, BR is likely a(n) _________ and AIN is likely a(n) _________ .
a.
oncogene; tumor-suppressor gene
b.
tumor-suppressor gene; tumor-suppressor gene
c.
oncogene; oncogene
d.
tumor-suppressor gene; viral gene
e.
tumor-suppressor gene; oncogene
You are studying the rate of transcription of a particular eukaryotic gene. When the DNA located several thousand bases upstream from the gene is removed, the transcription rate of the gene decreases dramatically. How would you interpret these results?
Chapter 11 Solutions
Campbell Essential Biology (6th Edition) - standalone book
Ch. 11 - Your bore cells, muscle cells, and skin cells look...Ch. 11 - A group of prokaryotic genes with related...Ch. 11 - The regulation of gene expression must be more...Ch. 11 - A eukaryotic gene was inserted into the DNA of a...Ch. 11 - How does DNA packing in chromosomes prevent gene...Ch. 11 - What evidence demonstrates that differentiated...Ch. 11 - The most common procedure for cloning an animal is...Ch. 11 - Prob. 8SQCh. 11 - Prob. 9SQCh. 11 - Prob. 10SQ
Ch. 11 - What is the difference between oncogenes and...Ch. 11 - Prob. 12SQCh. 11 - Prob. 13PSCh. 11 - The human body has a far greater variety of...Ch. 11 - Because a cat must have both orange and non-orange...Ch. 11 - Design a DNA microarray experiment that measures...Ch. 11 - Prob. 17PSCh. 11 - Prob. 18BSCh. 11 - Prob. 19BS
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- IS. Alternative splicing has been estimated to occur in more than 95% of multi-exon genes. Which of the following is not an evolutionary advantage of alternative splicing? Alternative splicing increases diversity without increasing genome size Different gene isoforms can be expressed in different tissues Alternative splicing creates shorter mRNA transcripts Different gene isoforms can be expressed during different stages of development.arrow_forwardDifferent forms of a protein are produced in the liver and in the brain by alternate splicing of its mRNA. How would a researcher clone the gene encoding that protein to study the form that was produced in the liver?arrow_forwardWhat is the purpose of alternative splicing a. Alternative spiicing allows a protein to be included by multiple genes b. Alternative spicing allows for mutations to accumulate that won't affect the expression of a gene c. Alternative splicing allows for multiple mRNAs to be produced to ensure that the single proteins the gene and codes will be translated. d.arrow_forward
- What is a difference between prokaryotic and eukaryotic gene expression? Please explain. Also, discuss briefly the significance in splicing, why this is done and how this leads into variety of different polypeptides.arrow_forwardWhich of the following is an example of a post-translational modification? Select an answer and submit. For keyboard navigation, use the up/down arrow keys to select an answer. a Splicing out introns! b Attachment of a poly-A tail! c Splicing out inteins! d Recruitment of 31 Mediator proteins that assemble around TATA.arrow_forwardWhen a region of DNA that contains the genetic information for a protein is isolated from a bacterial cell and inserted into a eukaryotic cell in a proper position between a promoter and a terminator, the resulting cell usually produces the correct protein. But when the experiment is done in the reverse direction (eukaryotic DNA into a bacterial cell), the correct protein is often not produced. Can you suggest an explanation?arrow_forward
- You are teaching a class on the regulation of eukaryotic gene expression. In order to demonstrate this complex process, you decide to draw for the class a typical eukaryotic gene/transcription unit with its major regions, such as the promoter regions, where the RNA polymerase II and transcription factors would bind From the list given - choose all components that you think are part of a typical eukaryotic gene From the list given - choose all the regulatory sequences that you think would control the expression of this eukaryotic gene From the list given - choose all of the regulatory proteins that would bind the eukaryotic gene to control its expressionarrow_forwardCompare and contrast different mechanisms of RNA splicing.arrow_forwardWould gene chips containing bacterial DNA segments be useful for monitoring gene expression in a mammalian cell?arrow_forward
- How many different polypeptides can be producedthrough alternative splicing of the same pre-mRNA?arrow_forwardIn general, why is it important to regulate genes? Discuss examples of situations in which it would be advantageous for a bacterial cell to regulate genes.arrow_forwardCan you please explain which sequences within the pre-mRNA determine where splicing occurs? How? Why?arrow_forward
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