Concept explainers
A man with hemophilia (a recessive, sex-linked condition) has a daughter without the condition, who marries a man who does not have hemophilia. What is the probability that their daughter will have the condition? Their son? If they have four sons, that all will be affected?
To determine:
The probability that son will have the hemophilia condition, when a man with hemophilia (a recessive, sex-linked condition) has a daughter without hemophilia who marries a man who does not have hemophilia. Determine whether all the four sons will be affected or not.
Introduction:
Hemophilia is a sex-linked disorder, which impairs the blood-clotting mechanism in the affected individuals. Those individuals who receive the non-functional gene from their parents must have X-chromosome linked to recessive trait.
Explanation of Solution
Consider the genotypes of daughter as H and h. As the male suffers from the hemophilic condition, the disorder is linked with the male chromosomes XY. The disorder is recessive and sex-linked. Here, the male chromosomes are considered as Hh. The probability that the daughter will be hemophilic is zero.
The female has one wild type allele (H) and one recessive mutant allele (h). The male has only wild-type allele and a Y chromosome. If the disorder is not linked with Y chromosome, then it is considered to be 0. The males received only one X chromosome, and hence, they have higher chances of carrying this disorder.
The sons have 50% chances of being affected by hemophilia. There is ½ probability that the sons are affected by the hemophilic condition.
Here, the Y chromosome does not contain hemophilia. Therefore, the hemophilic conditions are more dominant in sons.
As each son has a 50% chance of being affected by hemophilia, the probability of four sons is calculated as follows:
Here, the probability of all the sons who are affected is
The man with hemophilia and his daughter and son in law without this disease and the probability of acquiring this disease in his granddaughter is about 0. If he has a grandson, then it would be of ½ probability and in case if he has 4 grandsons, then it would be of 1/16 probability.
Want to see more full solutions like this?
Chapter 12 Solutions
CAMPBELL IN FOCUS BIOLOGY 107 CHAPTERS
Additional Science Textbook Solutions
Genetics: Analysis and Principles
Human Physiology: An Integrated Approach (7th Edition)
Human Biology: Concepts and Current Issues (8th Edition)
Essentials of Human Anatomy & Physiology (11th Edition)
Microbiology: An Introduction
Principles of Anatomy and Physiology
- An allele responsible for Marfan syndrome Section 13.4 is inherited in an autosomal dominant pattern. What is the chance that a child will inherit the allele if one parent does not carry it and the other is heterozygous?arrow_forwardWhat is a carrier of a genetic trait?arrow_forwardAssume that the ratio of females to males is 1:1. A couple already has two daughters and no sons. If they plan to have a total of six children, what is the probability that they will have four more girls? (a) (b) (c) 116 (d) 132 (e) 164arrow_forward
- Could an individual with blood type O (genotype ii) be a legitimate child of parents in which one parent had blood type A and the other parent had blood type B?arrow_forwardIf diseases such as cardiovascular disease (hypertension and atherosclerosis) are familial, is this an indication that there is a genetic contribution to these traits? What would you do to confirm that genetics is involved in this condition?arrow_forwardIn humans, hemophilia is a sex-linked recessive disease, and the gene is located on the X chromosome. A man with hemophilia marries a woman with hemophilia. What is the probability of a son they have been a hemophiliac?arrow_forward
- A man and woman are both heterozygous for the recessive allele that causes cystic fibrosis. What is the probability that their first two offspring will have the disorder?arrow_forwardWhat would be the expected phenotypes and genotypes of the children when a color blind man marries a normal woman?arrow_forwardA form of hemophilia is caused by a sex-linked (X-linked) recessive gene. A phenotypically normal woman whose father had hemophilia marries a phenotypically normal man with no family history of hemophilia. What is the probability that their first son will have hemophilia? 1/4 1 3/4 0 1/2arrow_forward
- Hemophilia is an X-linked recessive disorder and blood type is autosomal. If two healthy parents, one of which is blood type A and the other blood type B, produce a son who has hemophilia and is type O, what is the probability that their next child will be a son with hemophilia and blood type B? 1/2 3/16 1/4 1/8 1/16arrow_forwardIf a male is homozygous dominant and a female is heterozygous, what is the probability that their child will be homozygous recessive?arrow_forwardIn humans, hemophilia is a sex-linked recessive disease, and the gene is located on the X chromosome. A man with hemophilia marries a woman with hemophilia. What is the probability of a daughter they have been a hemophiliac?arrow_forward
- Biology (MindTap Course List)BiologyISBN:9781337392938Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. BergPublisher:Cengage LearningHuman Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage LearningBiology Today and Tomorrow without Physiology (Mi...BiologyISBN:9781305117396Author:Cecie Starr, Christine Evers, Lisa StarrPublisher:Cengage Learning
- Concepts of BiologyBiologyISBN:9781938168116Author:Samantha Fowler, Rebecca Roush, James WisePublisher:OpenStax CollegeHuman Biology (MindTap Course List)BiologyISBN:9781305112100Author:Cecie Starr, Beverly McMillanPublisher:Cengage Learning