EBK CAMPBELL BIOLOGY
11th Edition
ISBN: 9780134505589
Author: Urry
Publisher: PEARSON CO
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Textbook Question
Chapter 12, Problem 2TYU
Vinblastine is a standard chemotherapeutic drug used to treat cancer. Because it interferes with the assembly of microtubules, its effectiveness must be related to
- (A) disruption of mitotic spindle formation.
- (B) suppression of cyclin production.
- (C) myosin denaturation and inhibition of cleavage furrow formation.
- (D) inhibition of DNA synthesis.
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If a drug interferes with the formation of microtubules , its effectiveness must be related to
disruption of mitotic spindle formation
suppression of cyclin production
inhibition of DNA synthesis
myosin denaturation and inhibition of cleavage formation
What
experimental evidence indicates that cyclin B is re-quired for a cell to enter mitosis? What evidence indicates
that cyclin B must be destroyed for a cell to exit mitosis?
Why does catastrophe (the rate at which growing microtubules switch to a Contracting State) cause a decrease in the number and length of microtubules?
Chapter 12 Solutions
EBK CAMPBELL BIOLOGY
Ch. 12.1 - How many chromosomes are drawn in each part of...Ch. 12.1 - WHAT IF? A chicken has 78 chromosomes in its...Ch. 12.2 - How many chromosomes are shown in the illustration...Ch. 12.2 - Compare cytokinesis in animal cells and plant...Ch. 12.2 - During which stages of the cell cycle does a...Ch. 12.2 - Compare the roles of tubulin and actin during...Ch. 12.2 - A kinetochore has been compared to a coupling...Ch. 12.2 - MAKE CONNECTIONS What other functions do actin...Ch. 12.3 - In Figure 12.14, why do the nuclei resulting from...Ch. 12.3 - How does MPF allow a cell to pass the G2 phase...
Ch. 12.3 - MAKE CONNECTIONS Explain how receptor tyrosine...Ch. 12 - Differentiate between these terms: chromosome,...Ch. 12 - In which of the three phases of interphase and the...Ch. 12 - Explain the significance of the G1, G2, and M...Ch. 12 - Through a microscope, you can see a cell plate...Ch. 12 - Vinblastine is a standard chemotherapeutic drug...Ch. 12 - One difference between cancer cells and normal...Ch. 12 - The decline of MPF activity at the end of mitosis...Ch. 12 - In the cells of some organisms, mitosis occurs...Ch. 12 - Which of the following does not occur during...Ch. 12 - Cell A has half as much DNA as cells B, C, and D...Ch. 12 - The drug cytochalasin B blocks the function of...Ch. 12 - VISUAL SKILLS The light micrograph shows dividing...Ch. 12 - DRAW IT Draw one eukaryotic chromosome as it would...Ch. 12 - EVOLUTION CONNECTION The result of mitosis is that...Ch. 12 - SCIENTIFIC INQUIRY Although both ends of a...Ch. 12 - WRITE ABOUT A THEME: INFORMATION The continuity of...Ch. 12 - SYNTHESIZE YOUR KNOWLEDGE For selected answers,...
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- Between which two stages of the Neurospora life cycle do most mitotic cell divisions occur?arrow_forwardVinblastine is a standard chemotherapeutic drug used to treatcancer. Because it interferes with the assembly of microtubules,its effectiveness must be related to(A) disruption of mitotic spindle formation.(B) suppression of cyclin production.(C) myosin denaturation and inhibition of cleavage furrowformation.(D) inhibition of DNA synthesis.arrow_forwardOne important biological effect of a large dose of ionizing radiation (like X-rays) is to halt cell division. How does this occur? To answer this question, state the name and role of 2 specific and important proteins involved in the process. What happens if a cell has a mutation that prevents it from halting cell division after be irradiated? Be specific and detailed. An adult human who has reached maturity will die within a few days of receiving a radiation dose large enough to stop cell division. What does that tell you about cell division? In addition, name 2 different/unique cell types that would be primarily affected.arrow_forward
- What does cancer drugs play in interrupting mitosis of cancer cells? How do these drugs do that?arrow_forwardWhat are the three types of microtubules involved in the formation of the mitotic spindle? Briefly describe the contribution of each to successful cell division.arrow_forwardWhat is the function of mitotic spindle?arrow_forward
- In the mitosis experiment, in what stage were most of the onion root tip cells in? Based on what you know about cell cycle division, what does this imply about the life span of a cell? Were there any stages of the cell cycle that you did not observe? How can you explain this using evidence from the cell cycle?arrow_forwardIf cells in the process of dividing are subjected to colchicine, a drug that interferes with the functioning of the spindle apparatus, at which stage will mitosis be arrested?arrow_forwardWhich of the following changes to the microtubule binding protein, Tau, commonly occurs in Alzheimerâ s and other neurodegenerative diseases? A Tau is hypo-phosphorylated and does not bind to microtubules to destabilize them. B Tau levels are so low in the cell that they only bind to some microtubules. C Tau is hyper-phosphorylated and does not bind to microtubules to stabilize them. D Microtubules are hyper-phosphorylated and do not bind to Tau.arrow_forward
- Can we cure cancer by restoring the function of tumor suppressor proteins such as mutant p53 or pRb? If so, how is this possible?arrow_forwardWhat is spindle fibers??arrow_forwardWhy do most cancer treatments at present target microtubule formation of the cell? What are the most recent discoveries in terms of cancer treatment?arrow_forward
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