EBK ANATOMY & PHYSIOLOGY: THE UNITY OF
7th Edition
ISBN: 8220102796409
Author: SALADIN
Publisher: YUZU
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Chapter 12, Problem 3TYC
Suppose a poison were to slow down the Na+-K+ pumps of nerve cells. How would this affect the resting membrane potentials of neurons? Would it make neurons more excitable than normal, or make them more difficult to stimulate? Explain.
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Chapter 12 Solutions
EBK ANATOMY & PHYSIOLOGY: THE UNITY OF
Ch. 12.1 - Prob. 1BYGOCh. 12.1 - Prob. 2BYGOCh. 12.1 - Prob. 3BYGOCh. 12.1 - Prob. 1AYLOCh. 12.1 - Prob. 2AYLOCh. 12.1 - Prob. 3AYLOCh. 12.1 - Prob. 4AYLOCh. 12.2 - Prob. 4BYGOCh. 12.2 - Prob. 5BYGOCh. 12.2 - Prob. 6BYGO
Ch. 12.2 - Prob. 7BYGOCh. 12.2 - Prob. 1AYLOCh. 12.2 - Prob. 2AYLOCh. 12.2 - Prob. 3AYLOCh. 12.2 - Prob. 4AYLOCh. 12.2 - Prob. 5AYLOCh. 12.3 - Prob. 8BYGOCh. 12.3 - Prob. 9BYGOCh. 12.3 - Prob. 10BYGOCh. 12.3 - Prob. 1AYLOCh. 12.3 - Prob. 2AYLOCh. 12.3 - Prob. 3AYLOCh. 12.3 - Prob. 4AYLOCh. 12.4 - Prob. 11BYGOCh. 12.4 - Prob. 12BYGOCh. 12.4 - Prob. 13BYGOCh. 12.4 - Prob. 14BYGOCh. 12.4 - Prob. 15BYGOCh. 12.4 - Prob. 16BYGOCh. 12.4 - Prob. 17BYGOCh. 12.4 - Prob. 1AYLOCh. 12.4 - Prob. 2AYLOCh. 12.4 - Prob. 3AYLOCh. 12.4 - Prob. 4AYLOCh. 12.4 - Prob. 5AYLOCh. 12.4 - Prob. 6AYLOCh. 12.4 - Prob. 7AYLOCh. 12.4 - Prob. 8AYLOCh. 12.4 - Prob. 9AYLOCh. 12.5 - Prob. 18BYGOCh. 12.5 - Prob. 19BYGOCh. 12.5 - Prob. 20BYGOCh. 12.5 - Prob. 21BYGOCh. 12.5 - Prob. 1AYLOCh. 12.5 - Prob. 2AYLOCh. 12.5 - Prob. 3AYLOCh. 12.5 - Prob. 4AYLOCh. 12.5 - Prob. 5AYLOCh. 12.5 - Prob. 6AYLOCh. 12.5 - Prob. 7AYLOCh. 12.5 - Prob. 8AYLOCh. 12.5 - Prob. 9AYLOCh. 12.6 - Prob. 22BYGOCh. 12.6 - Prob. 23BYGOCh. 12.6 - Prob. 24BYGOCh. 12.6 - Prob. 25BYGOCh. 12.6 - Prob. 1AYLOCh. 12.6 - Prob. 2AYLOCh. 12.6 - Prob. 3AYLOCh. 12.6 - Prob. 4AYLOCh. 12.6 - Prob. 5AYLOCh. 12.6 - Prob. 6AYLOCh. 12.6 - Prob. 7AYLOCh. 12.6 - Prob. 8AYLOCh. 12.6 - Prob. 9AYLOCh. 12.6 - Prob. 10AYLOCh. 12.6 - Prob. 11AYLOCh. 12.6 - Prob. 12AYLOCh. 12.6 - Prob. 13AYLOCh. 12.6 - Prob. 14AYLOCh. 12 - The integrative functions of the nervous system...Ch. 12 - The highest density of voltage-gated ion channels...Ch. 12 - The soma of a mature neuron lacks a. a nucleus. b....Ch. 12 - The glial cells that fight infections in the CNS...Ch. 12 - Posttetanic potentiation of a synapse increases...Ch. 12 - An IPSP is_____of the postsynaptic neuron. a. a...Ch. 12 - Prob. 7TYRCh. 12 - Prob. 8TYRCh. 12 - Prob. 9TYRCh. 12 - Prob. 10TYRCh. 12 - Prob. 11TYRCh. 12 - Prob. 12TYRCh. 12 - Prob. 13TYRCh. 12 - Prob. 14TYRCh. 12 - Prob. 15TYRCh. 12 - A myelinated nerve fiber can produce action...Ch. 12 - Prob. 17TYRCh. 12 - Prob. 18TYRCh. 12 - Prob. 19TYRCh. 12 - Prob. 20TYRCh. 12 - Prob. 1BYMVCh. 12 - Prob. 2BYMVCh. 12 - Prob. 3BYMVCh. 12 - Prob. 4BYMVCh. 12 - Prob. 5BYMVCh. 12 - Prob. 6BYMVCh. 12 - Prob. 7BYMVCh. 12 - Prob. 8BYMVCh. 12 - Prob. 9BYMVCh. 12 - Prob. 10BYMVCh. 12 - Prob. 1TFCh. 12 - Prob. 2TFCh. 12 - Prob. 3TFCh. 12 - Prob. 4TFCh. 12 - Excitatory postsynaptic potentials lower the...Ch. 12 - Prob. 6TFCh. 12 - Prob. 7TFCh. 12 - Myelinated nerve fibers conduct signals more...Ch. 12 - Prob. 9TFCh. 12 - Prob. 10TFCh. 12 - Schizophrenia is sometimes treated with drugs such...Ch. 12 - Hyperkalemia is an excess of potassium ill the...Ch. 12 - Suppose a poison were to slow down the Na+-K+...Ch. 12 - Prob. 4TYCCh. 12 - Prob. 5TYC
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- Hyperkalemia was discussed at length in this module. If a cell is experiencing hyperkalemia, what could you do to get the action potential duration looking more like normal? a. Add more extracellular sodium b.Add more intracellular sodium c.Add more intracellular potassium d.Add more extracellular potassiumarrow_forwardDendrotoxins, produced by the mamba snakes (Dendroaspis), are inhibitors of the voltage-gated K+ channels. What phase of the action potential would this toxin affect? How would it affect ion permeability during this phase? How would ion movement be affected?arrow_forwardThe figure below may help in answering some of the questions. 1. What ions are flowing (and in which direction) both during the rising phase and the falling phase of the action potential? 2. What are the values of both the 'y' (vertical) axis and the 'x' (horizontal) axis. 3. If extracellular levels of K+ rose (a condition called hyperkalemia), how would that affect the resting membrane potential? 3arrow_forward
- What is the difference between inactivate and closed Na+ channels?Explain how a salty flavor is transduced into an action potential. Describe each step in an action potentialarrow_forwardWhich is TRUE about neuronal membrane electrical and concentration gradients at the peak of the action potential? The electrical gradient is in a direction that would tend to move K+ out of the cell. The concentration gradient for K+ is in a direction that would tend to move it into the cell. O The concentration gradient for K+ greatly increases compared to at rest. The concentration gradient for Na+ is in a direction that would tend to move it out of the cell. O The electrical gradient for Na+ is in a direction that would tend to move it into the cell.arrow_forwardIn the figure to the left, name the 4 phases of the action potential (Note: you have to write in where phase 4 occurs). Describe what happens in each phase with a focus on Na+ and K+ flow through channels and the membrane potential. Discuss the importance of threshold. How does this relate to the concept of APs being all or none?arrow_forward
- At the peak of the action potential, Vm is approximately -65 mV. Assuming normal intracellular and extracellular K+ concentrations (refer to the table), (1) calculate the driving force (in mV) that acts on K+ ions and (2) use the information obtained in part 1 to determine the direction in which K+ ions will flow (i.e., into the cell or out of cell)arrow_forwardA drug specifically blocks the Na+/K+ ATPase pump. What effect might this have on the action potential? O It will shorten the duration of the action potential as there will not be as many ions available to cross the membrane. None, as action potentials rely on channels for Na+ and K+ to cross the membrane, not pumps. It will not have an immediate effect, but eventually action potentials will stop as the Na+ and K+ gradients are depleted. It will make action potentials more likely to occur as the pump normally makes the cell more negative, so without it the membrane will reach threshold more easily.arrow_forwardEpilepsy is a condition which results in seizures stemming from excessive or abnormal activity of neurons. This can occur either from hyperexcitability of excitatory neurons, or impairment of inhibitory neurons. That is to say, either the excitatory pathways become overactive, or the inhibitory pathways, designed to temper the excitatory pathways, are not active enough. Much of the research done on epilepsy focuses on voltage-gated sodium channels, and to date over 700 different mutations to the channel have been identified as playing a role in epilepsy. The means by which these mutations contribute to epilepsy is quite complex, but for the sake of this CAL, let's simplify and apply what we have learned so far to identify potential mechanisms for this condition. In what way could voltage-gated sodium channels be affected in excitatory neurons which would increase the likelihood of the neuron firing an action potential? (one correct answer) The inactivation gate is slower to close. The…arrow_forward
- In an experiment, the extracellular [Na+] surrounding a nerve cell was reduced from 145 to 45 mM. Which of the following is the most likely effect of this on action potentials? No action potentials would occur because the concentration of extracellular Na+ is too low. The membrane potential would become more negative so the threshold for action potential generation could not be reached. The nerve cell would still produce an action potential but its amplitude would be reduced and the depolarisation phase would be slower. The nerve cell would still produce an action potential but its amplitude would be reduced and the depolarization phase would be more rapid.arrow_forwardBased upon the changes in permeability seen in the trace below and your knowledge of ion distributions across a cell, predict how ion movements would change during an action potential. Drag and drop each phrase into the appropriate box on the action potential trace. Drag the appropriate labels to their respective targets. Note: not all labels will be used. ►View Available Hint(s) Sodium (Na+) ions move to the axon Sodium (Na) ions move out of the axon Less potassium (K) ions move out of the axon Potassium (K) ions move out of the axon Potassium (K¹) ions move into the axon Sodium (Na) ions stop moving in Membrane potential (mv) +30 +10 0 -10- -30 -50 -70 -90 A PNa 0 PNa 5 6 1 PK Threshold PK 2 Reset Helparrow_forwardExplain different ways in which invertebrates and vertebrates have achieved high velocities for conduction of action potentials. Can you suggest why the invertebrate solution would not be suitable for the homeothermic birds and mammals?arrow_forward
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