BIOLOGY DUAL ENROLLMENT VERSION
BIOLOGY DUAL ENROLLMENT VERSION
12th Edition
ISBN: 9780136681311
Author: Urry
Publisher: PEARSON
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Chapter 12.2, Problem 5CC

A kinetochore has been compared to a coupling device that connects a motor to the cargo that it moves. Explain.

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Let's say that an experiment resulted in the production of several unattached kinetochores. What effect, if any, would this have on (i) the duration (length) of the mitotic phase, (ii) the timing of cyclin B’s appearance or disappearance, and (iii) the period of time for which MPF is active?  Briefly explain your reasoning.
Let's say that an experiment had no disruption to kinetochores and you are able to inactivate the CDC 14 phosphatase, which acts to remove phosphate groups from substrates that were previously phosphorylated by active MPF.  What effect, if any, would this have on (i) the duration (length) of the mitotic phase, (ii) the timing of cyclin B’s appearance or disappearance, and (iii) the period of time for which MPF is active?  Briefly explain your reasoning
What are the mechanisms by whichmicrotubule attachment and tensionare sensed at the kinetochore by thecomponents of the spindle assemblycheckpoint?

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BIOLOGY DUAL ENROLLMENT VERSION

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