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Transgenic Animals as Models of Human Diseases You are a neuroscientist working on a particular neurodegenerative disease and discover that the disease is caused by the expression of a mutant gene in the brain. A colleague suggests that you use this new information to develop a transgenic mouse model of the disease. How might you do this? How would you use the animal to study the disease or look for new treatments?

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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 14, Problem 7QP
Textbook Problem
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Transgenic Animals as Models of Human Diseases

You are a neuroscientist working on a particular neurodegenerative disease and discover that the disease is caused by the expression of a mutant gene in the brain. A colleague suggests that you use this new information to develop a transgenic mouse model of the disease. How might you do this? How would you use the animal to study the disease or look for new treatments?

Summary Introduction

To determine: The method of development of a transgenic mouse model with a particular neurodegenerative disease.

Introduction: A model organism is an organism which has about 90% genes identical to the humans and on which the studies of human diseases can be conducted. A model organism should be small and have short generation time so that biological studies can be conducted on them conveniently. Drosophila melanogaster and Mus musculus are certain examples of model organisms used to study human diseases.

Explanation of Solution

The construction of mouse models to study inherited human diseases is done by transferring mutant human disease alleles into the mice.

The method of development of a transgenic mouse model with a particular human neurodegenerative disease which is caused by a mutant gene is as follows:

  • • The mutant gene is extracted and isolated from the diseased individual.
  • • These isolated mutant genes are then cloned into vectors and microinjected into the nuclei of fertilized eggs of the mouse...
Summary Introduction

To determine: The use of model organism to study the disease or look for new treatments.

Introduction: A model organism is an organism which has about 90% genes identical to the humans and on which the studies of human diseases can be conducted. A model organism should be small and have short generation time so that biological studies can be conducted on them conveniently. Drosophila melanogaster and Mus musculus are certain examples of model organisms used to study human diseases.

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