Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 15, Problem 13P
Suppose a new mutation arises in a mitochondrial genome. Explain what would have to happen in order for the mutation to express itself
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Explain how mutations in mitochondrial genes cause humandiseases
The DNA located inside of mitochondria exhibits approximately ten times the mutation rate seen in nuclear DNA. Provide an explanation as to why this is the case and what are the effects of this higher mutation rate of mitochondrial DNA on disease processes?
A mitochondrial transfer technique may offer a potential solution for women with mtDNA-based diseases to have healthy children.This technique works by replacing the damaged mitochondria in the mother’s egg with healthy mitochondria from another woman’s donor egg. Based on what you know about the importance of nuclear gene products to mitochondrial functions, will this technique ensure that children will not inherit or develop a mtDNA-based diseases?
Chapter 15 Solutions
Genetics: From Genes to Genomes
Ch. 15 - Match each numbered item with the most closely...Ch. 15 - Assuming human cells have on average 1000...Ch. 15 - Reverse translation is a term given to the process...Ch. 15 - The human nuclear genome encodes tRNAs with 32...Ch. 15 - The human mitochondrial genome includes no genes...Ch. 15 - How do you know if the halibut you purchased at...Ch. 15 - Is each of these statements true of chloroplast or...Ch. 15 - Suppose you are characterizing the DNA of a...Ch. 15 - An example of a gene-targeting DNA plasmid vector...Ch. 15 - Which of the following characteristics of...
Ch. 15 - The Saccharomyces cerevisiae nuclear gene ARG8...Ch. 15 - The so-called hypervariable regions HV1 and HV2 of...Ch. 15 - Suppose a new mutation arises in a mitochondrial...Ch. 15 - Describe at least two ways in which the...Ch. 15 - Why are severe mitochondrial or chloroplast gene...Ch. 15 - Suppose you are examining a newly found plant...Ch. 15 - A form of male sterility in corn is inherited...Ch. 15 - Plant breeders have long appreciated the...Ch. 15 - A mutant haploid strain of Saccharomyces...Ch. 15 - Prob. 20PCh. 15 - What characteristics in a human pedigree suggest a...Ch. 15 - The first person in the family represented by the...Ch. 15 - In 1988, neurologists in Australia reported the...Ch. 15 - If you were a genetic counselor and had a patient...Ch. 15 - Kearns-Sayre syndrome KSS, Pearson syndrome, and...Ch. 15 - Many clinically relevant mitochondrial diseases...Ch. 15 - Leigh syndrome is characterized by psychomotor...Ch. 15 - All mutations in mitochondrial genes ultimately...Ch. 15 - How could researchers have determined that the...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Domestic dogs are closely related to wolves. Wolves have one copy of the gene that encodes the enzyme amylase. Amylase is required to digest starch. Dogs have between 4 and 30 copies of this gene. Explain how the new copies arose in the genome of the domestic dog. Compare this to the evolution of lactase persistence in humans. Explain how the diet and environment of a dog compared to a wolf would result in fixation of the duplicated gene. What possible explanation is there for the variation of copy number among dog breeds?arrow_forward99% of mitochondria are inherited from the mother. Mitochondria are thus primarily passed on from mother to offspring. Draw a pedigree showing a pattern that suggests a mitochondrial gene mutation. Explain step by step.arrow_forwardIs each of these statements true of chloroplast or mitochondrial genomes, both, or neither?a. contain tRNA genesb. encode proteins that participate in electron transport pathwaysc. all genes necessary for function of the organelleare presentd. vary greatly in size from organism to organismarrow_forward
- How many copies of mitochondrial 16S rRNA gene are integrated in Human chromosomal DNA ?arrow_forwardIn humans, the AMY1 gene produces the enzyme amylase in cells of the salivary glands. Amylase breaks down starch (a polysaccharide) into the sugar maltose (a disaccharide). People from cultures with diets high in starch produce more amylase than people from cultures with diets low in starch because of a mutation in the AMY1 gene. Explain in two to three sentences why the frequency of this AMY1 mutation would have increased in frequency in populations with a high starch diet.arrow_forwardExplain the likely evolutionary origin of mitochondrial and chloroplast genomes. How have the sizes of the mitochondrial and chloroplast genomes changed since their origin? How has thisoccurred?arrow_forward
- A mother has a high heteroplasmic load in her germ cells (cells that will produce her eggs). Which of the following statements is correct? A. ALL of her offspring are guaranteed to inherit the disease associated with this heteroplasmic load. B. She can only pass the mitochondrial mutation to her daughters. C. ALL of her eggs that can potentially be fertilized will have a high heteroplasmic load. D. Cell division could lead to uneven distribution of mitochondria.arrow_forwardExplain the effect of one, two or all three introns removal from the Hes7 gene would reduce the delay the production of the unstable Hes7 gene.arrow_forwardWhich of the following best characterizes human mitochondrial mutations?` They are sex linked. They are paternally inherited. They are pleiotropic. Phenotype is usually restricted to a single process or trait.arrow_forward
- During the course of a research project you generate a gene knockout line in Arabidopsis thaliana to study the function of a gene you believe plays a crucial role in cellular metabolism. You note that the initial transformants are a bit smaller than normal. In subsequent crosses you are unable to isolate homozygotes for the knockout allele. Heterozygotes in subsequent generation are still a bit smaller than the homozygous wild type plants. Explain what is happening.arrow_forwardexplain RNA editing of mitochondrial gene transcriptsarrow_forwardThe mitochondrial genome of Chlamydomonas contains the lowest number of genes, 12, of all the species of green algae. However, only 7 proteins are produced inside these mitochondria. Which of the following statements is the best explanation for why only 7 proteins are made from the 12 genes In Chlamydomonas mitochondria? OA Five of the genes are redundant; another copy is expressed from the nuclear genome.. OB. Five of the genes are nonfunctional "pseudogenes". OC Five of the genes are transcribed, but not translated. OD. Five of the genes are coding for proteins that are translated in the cytoplasm. Reset Selectionarrow_forward
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Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY