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Jan is concerned about using ART. She wants to be the genetic mother and have Darryl be the genetic father of any children they have. What methods of ART would you recommend to this couple?
Jan, a 32-year-old woman, and her husband, Darryl, have been married for 7 years. They have attempted to have a baby on several occasions. Five years ago, they had a first-trimester miscarriage, followed by an ectopic pregnancy later the same year. Jan continued to see her OB/GYN physician for infertility problems but was very dissatisfied with the response. After four miscarriages, she went to see a fertility specialist, who diagnosed her with severe endometriosis and polycystic ovarian disease (detected by hormone studies). The infertility physician explained that these two conditions were hampering her ability to become pregnant and thus making her infertile. She referred Jan to a genetic counselor.
At the appointment, the counselor explained to Jan that one form of endometriosis (MIM 131200) can be a genetic disorder, and that polycystic ovarian disease can also be a genetic disorder (MIM 184700) and is one of the most common reproductive disorders among women. The counselor recommended that a detailed family history of both Jan and Darryl would help establish whether Jan’s problems have a genetic component and whether any of her potential daughters would be at risk for one or both of these disorders. In the meantime, Jan is taking hormones, and she and Darryl are considering alternative modes of reproduction.
Using the information in Figure 16.4, explain the reproductive options that are open to Jan and Darryl.
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Chapter 16 Solutions
HUMAN HEREDITY (LL)-W/MINDTAP ACCESS
- Question:- Ben and Elise are pregnant with their 3rd child. The two prior pregnancies resulted in healthy boys but they are still concerned because Elise's first cousin was just diagnosed with DMD (Duchene muscular dystrophy – x-linked). Ben has three healthy brothers and no aunts or uncles. Elise has two healthy brothers and only the one maternal aunt with the son with DMD. What is the chance that Ben and Elise will have a child with DMD? a.1/20 b.1/140 c.1/209arrow_forwardThe woman in Problem 24 has had two miscarriages. She has come to you, an established genetic counselor, with these questions: Is there a genetic explanation of her frequent miscarriages? Should she abandon her attempts to have a child of her own? If not, what is the chance that she could have a normal child? Provide an informed response to her concerns.arrow_forwardYou met with two parents whose first child has sickle cell anemia. (The parents show no signs of the disease themselves). The mother comes to you in the third month of her second pregnancy, and wants to know if this child will also inherit the disease. As a genetics counselor, you are ready to evaluate this couple’s case by doing the following:1. Determine what the genotype of each parent is. Is this disease autosomal or sex-linked? Dominant or recessive?arrow_forward
- Ten years into the future and you have just become a parent of a new born baby who apparently appears healthy. Will you subject your child to genetic testing? Support your answer in 3-4 sentences. only 3-4 sentences thank you.arrow_forwardWhat is the karyotype for women who have an extra X-chromosome? Discuss all the ways you can test for this abnormality.arrow_forwardA couple, who are both normal, have a daughter who is albino and a son who is normal. a) what is the probability that their normal son is a carrier of the albinism gene? Show your work. b) the couple wants to have 3 more children; what is the probability that they will have 3 normal girls? Show your work.arrow_forward
- Mrs. Xexy Lucero, G0, who is planning to become pregnant tells Nurse Sasha, "I am scared. My brother Zanjo, who was born 2 years after I was, died a month after he was born. My mother says that he had a very serious genetic defect. I don't know what to do." Which of the following responses are appropriate for Nurse Zasha to make? (Select all that apply). a. I Think your mother should make an appointment to meet with your obstetrician. I'm sure she knows a lot more about your brother's illness than she is telling you." b. There are a number of tests that can be performed during your pregnancy tO Screen the baby for genetic diseases." c. lt is almost impossible to figure out what happened way back then, but l'm sure everything will be fine with your baby." d. Do you think your mother would allow your brother's body to be unearthed so that it could be tested for the genetic disease? e. I will discuss your concerns with your Obstetrician. I am sure your doctor will refer you to agenetic…arrow_forwardMrs. Dee (40 years old) and her husband have an amniocentesis for advanced maternal age. They already have four healthy children. They receive results indicating a 47,XXY karyotype. What is the phenotypic sex of the fetus? How many Barr bodies will be found in each somatic cell?arrow_forwardState who the genetic parents are and who the gestational mother is in each of the following cases:a. A man was exposed to unknown burning chemicals and received several vaccines while serving in the U.S. military in Iraq, and abused drugs for several years before and after that. Now. he wants to become a father, but he is concerned that past exposures to toxins have damaged his sperm. His wife undergoes intrauterine insemination with sperm from the husband’s brother, who has led a calmer and healthier life b. A 26-year-old woman has her uterus removed because of cancer. However, her ovaries are intact and her oocytes are healthy. She has oocytes removed and fertilized in vitro with her husband’s sperm. Two resulting embryos are implanted into the uterus of the woman’s bestfriend.c. Max and Tina had a child by IVF and froze three extra embryos. Two are thawed years later and implanted into the uterus of Tina’s sister, Karen. Karen’s uterus is healthy, but she has ovarian cysts that…arrow_forward
- A male presenting with clinical features as greater height, poor coordination, less body hair, breast growth and seems less interest in sex. He is also facing difficulty in speech. What your knowledge depicts that he is suffering from which genetic disease.arrow_forwardMrs. Kern and her wife have arrived in the OB clinic where you are working. Mrs. Kern became pregnant through in vitro fertilization at the age of 39 years, and the couple is now inquiring about further testing for genetic concerns in her 16th week of pregnancy. What tests would you expect the provider to recommend? Select all that apply. Alpha-fetoprotein hCG levels Cell-free fetal DNA Preimplantation genetic diagnosis Level II ultrasoundarrow_forwardIf the mutation occurred in Jonathan's somatic cells when he was in his 30's, what type of alleles will be found in his sperm? Select an answer and submit. For keyboard navigation, use the up/down arrow keys to select an answer. b [+ 50% will contain the mutant Huntington allele, 50% will contain the wildtype allele. 25% will contain the mutant Huntington allele, 75% will contain the wildtype allele. Since Huntington's Disease is a dominant disorder, all of his sperm will contain mutant Huntingtin alleles. The condition will not appear in his gametes since he did not inherit it, but it arose as a new mutation in his body cells.arrow_forward
- Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning
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