Molecular Cell Biology
Molecular Cell Biology
8th Edition
ISBN: 9781464183393
Author: Harvey Lodish, Arnold Berk, Chris A. Kaiser, Monty Krieger, Anthony Bretscher, Hidde Ploegh, Angelika Amon, Kelsey C. Martin
Publisher: W. H. Freeman
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Chapter 16, Problem 9RTC
Summary Introduction

To write:

The function of the PTEN phosphatase in the PI-3 kinase signaling pathway. The loss of function mutation in PTEN promotes cancer. The prediction of the constitutively active PTEN effect on cell growth and survival.

Introduction:

Phosphatase and tensin homolog (PTEN) area type of protein, that is produced by the PTEN gene, in humans. PTEN behaves as a tumor suppressor gene by the activity of its phosphatase protein product. This phosphatase helps in the cell cycle regulation thereby, preventing the rapid growth and division of cells. Fork-head motif or winged helix is due to the butterfly-like presence of the loops in the domain protein structure.

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Intro to Cell Signaling; Author: Amoeba Sisters;https://www.youtube.com/watch?v=-dbRterutHY;License: Standard youtube license