Could a gene be involved in the growth of both stem cells and some kinds of cancer? Explain your answer.

Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter12: Genes And Cancer
Section12.10: Genomics, Epigenetics,and Cancer
Problem 2GR: Another model, the random model, proposes that any cell in a malignant tumor has the potential to...
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Could a gene be involved in the growth of both stem cells and some kinds of cancer? Explain your answer.

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in stem cells we have an important class of genes called proto-oncogenes [PO] with are necessary for the proliferation and apoptosis of faulty cells.

when such genes become mutated they become oncogenes which are responsible for transforming the stem cell to cancer stem cells. these cells are capable of metastasis and reactivation of tumours in cured patients

along with PO, tumour suppressor genes are also required to ensure that the stem cell does not undergo uncontrolled proliferation on an oncogene is made  by mutations

 

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