Concept explainers
(a)
Interpretation: The hybridization of each nitrogen atom in methotrexate is to be predicted.
Concept introduction: Hybridization is the combination of two or more atomic orbitals to form the same number of hybrid orbitals, each having the same shape and energy. Number of groups around the atom is equal to number of the number of orbitals hybridized to give hybrid atomic orbitals.
(b)
Interpretation: The type of orbital in which the lone pair of nitrogen atom resides is to be predicted.
Concept introduction: Hybridization is the combination of two or more atomic orbitals to form the same number of hybrid orbitals, each having the same shape and energy. Number of groups around the atom is equal to number of the number of orbitals hybridized to give hybrid atomic orbitals.
(c)
Interpretation: The reason corresponding to the fact that the bicyclic ring in methotrexate is
Concept introduction: A molecule must be cyclic, planar, completely conjugated and should follow
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- Organic ChemistryChemistryISBN:9781305580350Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. FootePublisher:Cengage Learning