GENETICS(LL)-W/CONNECT >CUSTOM<
6th Edition
ISBN: 9781260571561
Author: HARTWELL
Publisher: MCG CUSTOM
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Textbook Question
Chapter 17, Problem 28P
Honeybees (Apis mellifera) provide a striking example of environmental effects on eukaryotic gene expression and thus
It turns out that the diet of the larval (larvae are young developing insects) females controls their development as either workers or queens. When the hive needs new queens, a few female larvae are fed royal jelly, a substance secreted by worker bees, instead of the normal diet of nectar and pollen. Investigators determined that many genes are more highly CpG-methylated in the larval-stage workers than in the larval-stage queens
a. | Describe an experiment you could do to determine if DNA methylation correlates with differences in gene expression in workers and queens. |
b. | Researchers were able to mimic the effect of royal jelly by knocking down the expression in female larvae of a DNA methyltransferase enzyme called DNMT3. (The knockdown was accomplished through a technique called RNA interference that is described in a later problem; the details are unimportant here.) Remarkably, when fed a normal diet, most of these larvae developed as queens. Based on the description of the transgenerational silencing of the
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In a mutant mouse, it was discovered that a gene "W" is moved from its original chromosomal locus to the telomere region, where chromatin is packed into heterochromatin. Given what we have learned about eukaryotic gene regulation, can you speculate how the expression of gene W in the new mouse line would be changed as compare to the normal mouse?
Question 18 options:
elevated in the mutant mouse than in the wild-type mouse.
cannot be determined.
reduced in the mutant mouse than in the wild-type mouse.
no change in the mutant mouse as compared to the wild-type mouse.
Discuss the morphological differences between the parasegments and segments of Drosophila. Discuss the evidence, providing specific examples, that suggests the parasegments of the embryo are the subdivisions for the organization of gene expression.
In a mutant mouse, it was discovered that a gene "W" is moved from its original
chromosomal locus to the telomere region, where chromatin is packed into
heterochromatin. Given what we have learned about eukaryotic gene regulation, can
you speculate how the expression of gene W in the new mouse line would be
changed as compare to the normal mouse?
elevated in the mutant mouse than in the wild-type mouse.
cannot be determined.
O reduced in the mutant mouse than in the wild-type mouse.
change in the mutant mouse as compared to the wild-type mouse.
Chapter 17 Solutions
GENETICS(LL)-W/CONNECT >CUSTOM<
Ch. 17 - For each of the terms in the left column, choose...Ch. 17 - For each of the following types of gene...Ch. 17 - List five events other than transcription...Ch. 17 - Which eukaryotic RNA polymerase RNA pol I, pol II,...Ch. 17 - As shown in the following diagram, a single...Ch. 17 - You have synthesized an enhancerless GFP reporter...Ch. 17 - Prob. 7PCh. 17 - Prob. 8PCh. 17 - A single UAS regulates the expression of three...Ch. 17 - MyoD is a transcriptional activator that turns on...
Ch. 17 - a. Assume that two transcription factors are...Ch. 17 - Prob. 12PCh. 17 - In Problem 12, you identified a genomic region...Ch. 17 - Prob. 14PCh. 17 - Prob. 15PCh. 17 - Genes in both prokaryotes and eukaryotes are...Ch. 17 - Prob. 17PCh. 17 - Lysine 4 of histone H3 H3K4 is methylated in the...Ch. 17 - J.T. Lis and collaborators have developed an...Ch. 17 - Hydatiform moles are growths of undifferentiated...Ch. 17 - Prader-Willi syndrome is caused by a mutation in...Ch. 17 - The human IGF2 gene is autosomal and maternally...Ch. 17 - Follow the expression of a paternally imprinted...Ch. 17 - Reciprocal crosses were performed using two inbred...Ch. 17 - Interestingly, imprinting can be tissue-specific....Ch. 17 - Prob. 26PCh. 17 - A method for detecting methylated CpGs involves...Ch. 17 - Honeybees Apis mellifera provide a striking...Ch. 17 - Consider the experiment in Fig. 17.24, where the...Ch. 17 - A protein or RNA that regulates gene expression in...Ch. 17 - a. How can a single eukaryotic gene give rise to...Ch. 17 - A hunchback gene, a gene necessary for proper...Ch. 17 - You know that the mRNA and protein produced by a...Ch. 17 - You are studying a transgenic mouse strain that...Ch. 17 - Prob. 35PCh. 17 - Scientists have exploited the siRNA pathway to...Ch. 17 - Persimmons Diospyros lotus are dioecious plants,...Ch. 17 - Drosophila females homozygous for loss-of-function...Ch. 17 - The text has discussed the RNA-Seq technique,...Ch. 17 - Researchers know that Fru-M controls male sexual...Ch. 17 - The Drosophila gene Sex lethal Sxl is deserving of...Ch. 17 - Figure 17.29 shows that the Sxl protein binds to...
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