BIOLOGY 12TH ED (LL) W/ CONNECT
12th Edition
ISBN: 9781264898091
Author: Raven
Publisher: MCG
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Textbook Question
Chapter 17, Problem 4U
FISH analysis of a breast tumor biopsy for HER2 gene reveals two spots of fluorescence in cells. What conclusion do these data support about the tumor?
a. It is likely to contain high levels of the HER2 mRNA.
b. It is likely to contain high levels of the HER2 protein.
c. The HER2 gene is amplified, and treatments targeting the HER2 protein may not be suitable.
d. The HER2 gene is not amplified, and so particular treatments targeting the HER2 protein may not be suitable.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Gene expression array technology has been used to do which of the following (select all that apply)?
A.
Determine liklihood of metastasis
B.
Determine the most relevant treatment for individual patients based on their genomic “signature.”
C.
Determine therapeutic index of cancer drug
D.
Predict the likelihood of disease recurrence in individuals based on gene expression signatures
E.
Stratify patients with breast cancer into groups predictive of response to therapy
Which of the following statements are true about the rate of mutation in tumor cells (select all that apply)?
A.
Mutation rate of tumor cells is reduced compared to normal cells of the same tissue type
B.
Mutation rate of tumor cells is unchanged compared to normal cells of the same tissue type
C.
Mutation rate in tumor cells is higher compared to normal cells of the same tissue type
D.
Affected by genome instability within the tumor cells
A. Which genes could be used to monitor the process of the disease?
B.  If you worked for a drug company developing a treatment for the cancer, which genes would you target to turn on in cancer cells?
C. Which genes would you target to turn off in cancer cells?
Chapter 17 Solutions
BIOLOGY 12TH ED (LL) W/ CONNECT
Ch. 17.1 - Prob. 1LOCh. 17.1 - Prob. 2LOCh. 17.1 - Describe the construction and uses of recombinant...Ch. 17.2 - Relate the process of DNA replication to PCR.Ch. 17.2 - Compare and contrast PCR, RT-PCR, and quantitative...Ch. 17.3 - Prob. 1LOCh. 17.3 - Prob. 2LOCh. 17.3 - Describe the pros and cons of RNA interference and...Ch. 17.4 - Explain how the universal nature of the genetic...Ch. 17.4 - Compare and contrast knockout, knockin, and...
Ch. 17.4 - Prob. 3LOCh. 17.5 - Describe the benefits of biofuel production from...Ch. 17.5 - Prob. 2LOCh. 17.5 - Prob. 3LOCh. 17.6 - Prob. 1LOCh. 17.6 - Compare and contrast FISH and gene chip...Ch. 17.6 - Describe how immunoassays can be used to diagnose...Ch. 17.7 - Describe the benefits of creating transgenic...Ch. 17.7 - Prob. 2LOCh. 17.7 - Evaluate issues on each side of the transgenic...Ch. 17 - Prob. 1DACh. 17 - Prob. 2DACh. 17 - Prob. 1IQCh. 17 - Prob. 2IQCh. 17 - You study a gene known to be important in the...Ch. 17 - What is the basis of separation of different DNA...Ch. 17 - Prob. 3UCh. 17 - FISH analysis of a breast tumor biopsy for HER2...Ch. 17 - In terms of studying gene function, what is the...Ch. 17 - The Ti plasmid of Agrobacterium usually induces...Ch. 17 - Prob. 1ACh. 17 - Which of the following statements is accurate for...Ch. 17 - Prob. 3ACh. 17 - Many human proteins, such as hemoglobin, are only...Ch. 17 - Amyloid beta is a proteolytic product of a protein...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Comparative proteomics involves comparing the proteomes from two different cells or tissues from different conditions. In some cancer cells the Retinoblastoma protein often appears to have a slightly higher molecular mass than in noncancerous cells even though the proteins have identical amino acid sequences. What might explain this difference? a. Posttranslational modification b. Alternative splicing c. Association with different proteins d. Mutation of the gene encoding the proteinarrow_forwardRASL11A gene is a tumor suppressor gene associated with spontaneous tumor shrinkage in Tasmanian Devils. In those tumors that shrink, the expression of RASL11A is: Group of answer choices a. upregulated compared to the expression in tumors that proliferate. b. downregulated compared to the expression in tumors that proliferate. c. the same as in those tumors the expression in tumors that proliferate. While studying tumor cells, you notice that the histones of a particular chromosome have more acetyl groups bound to them in tumor cells, compared to the same chromosome in healthy cells. What would you expect for the amount of proteins encoded by genes on that chromosome in tumor cells compared to healthy cells? Group of answer choices a. Higher in tumor cells b. Lower in tumor cells c. Similar in tumor and healthy cellsarrow_forwardDescribe error prone polymerases and the process of translesion synthesis (TLS). In regards to tumor biology, what is the mutator phenotype hypothesis? What are some ways in which error-prone polymerases could be targeted for potential anti-cancer treatments?arrow_forward
- Pls answer the questionarrow_forwardWhich of the following is true? a. Enhancers are proteins that bind to activator DNA sequences. b. Activators are proteins that bind to insulator sequences c. Repressors are proteins that bind to enhancer DNA sequences. d. Repressors are proteins which bind to silencer DNA sequencers.arrow_forwardE. coli are grown on a medium containing lactose. Once glucose is added to the medium, the bacteria stop fermenting lactose. Which of the following BEST explains the observed effect? A. Cellular levels of cAMP are lowB.Glucose is bound to the promoter C. Repressor protein is bound to the operator D. Repressor protein is bound to the promoterarrow_forward
- Which of the following steps are correct about multistep tumorigenesis (select all that apply)? A. Mutations in progenitor cells are more likely to develop a neoplastic state compared to mutations in stem cells B. Driver mutations give a cell clone a proliferative advanage C. The rate of mutation /genetic change is constant during tumor progression D. Nutrition/diet may effect rate of tumorigenesis E. All cells within a tumor are biologically equivalent and equally capable of high levels proliferationarrow_forwardYou are studying pancreatic cancer have matched samples of tumor and healthy pancreatic tissue. You use a microarray to determine gene expression differences between these two sample. You label the healthy tissue cDNA with red fluorescnce and the tumor cDNA with green. You apply these cDNAs to your chip. Beta-actin is a housekeeping gene required for cell structure. What color would you expect the spot for this gene to be? a. Red b. Green c. Yellow d. No color e. None of the abovearrow_forward1). Tumor suppressor proteins monitor DNA and detect damage. Some cancers evade this detection by removing tumor suppressor proteins from the nucleus. An overproduction of what transport molecule could cause this? What is one example of how this overproduction might be targeted for cancer treatment (suggest a hypothetical treatment that would prevent the cancer)? 2) :) Based on the course content thus far, would mRNA vaccines pose a risk to the genomic DNA in a cell? Explain.arrow_forward
- Different gene therapy approaches have been studied for cancer gene therapy. These approaches include? (select all that applies) a.immunotherapy, b. anti-angiogenic gene therapy, c.inhibition of tumor invasion, d.induction of apoptosisarrow_forwarda. Why would a mutation in BRCA1 be considered a driver mutation? b. Based on what you’ve learned thus far, would ATM be considered a tumor suppressor? Explain your reasoning.arrow_forward1a) Why is it possible for you to study the eye colour gene by extracting cheek cells? a. Because the nucleus of every cell in the human body contains the same genetic information. b. Because the cheek cells are located near the cells of the eye and so they are able to exchange DNA. c. Because all genes in the human body are expressed at all times so it is easy to study them. d. All of the above are possible explanations. 1b) What is the purpose of heating the sample to 75°C following addition of the 0.2M NaOH solution? a. To denature the histone proteins that are keeping the DNA tightly coiled. b. To ensure that all the DNA is removed from the swab in preparation for PCR. c. To breakdown the cheek cell membrane to release the DNA from the cell. d. It breaks down the circular DNA down into linear fragments so that they will be easier to visualize.iarrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)BiologyISBN:9780134580999Author:Elaine N. Marieb, Katja N. HoehnPublisher:PEARSON
Biology 2eBiologyISBN:9781947172517Author:Matthew Douglas, Jung Choi, Mary Ann ClarkPublisher:OpenStax
Anatomy & PhysiologyBiologyISBN:9781259398629Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa StouterPublisher:Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)BiologyISBN:9780815344322Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter WalterPublisher:W. W. Norton & Company
Laboratory Manual For Human Anatomy & PhysiologyBiologyISBN:9781260159363Author:Martin, Terry R., Prentice-craver, CynthiaPublisher:McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)BiologyISBN:9781260231700Author:Sylvia S. Mader, Michael WindelspechtPublisher:McGraw Hill Education
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:PEARSON
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax
Anatomy & Physiology
Biology
ISBN:9781259398629
Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:9780815344322
Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:9781260159363
Author:Martin, Terry R., Prentice-craver, Cynthia
Publisher:McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Biology
ISBN:9781260231700
Author:Sylvia S. Mader, Michael Windelspecht
Publisher:McGraw Hill Education
An Introduction to the Human Genome | HMX Genetics; Author: Harvard University;https://www.youtube.com/watch?v=jEJp7B6u_dY;License: Standard Youtube License