(a)
Interpretation: Hagemann’s ester is to be prepared by the use of a mixture of ethyl acetoacetate and formaldehyde as starting materials.
Concept introduction: The reaction of preparation of Hagemann’s ester follows a series of steps. In first step, a base abstracts a proton from the
(b)
Interpretation: Hagemann’s ester is to be prepared by the use of a mixture of ethyl acetoacetate and formaldehyde as starting materials.
Concept introduction: The reaction of preparation of Hagemann’s ester follows a series of steps. In first step, a base abstracts a proton from the
(c)
Interpretation: Hagemann’s ester is to be prepared by the use of a mixture of ethyl acetoacetate and formaldehyde as starting materials.
Concept introduction: The reaction of preparation of Hagemann’s ester follows a series of steps. In first step, a base abstracts a proton from the
(d)
Interpretation: Hagemann’s ester is to be prepared by the use of a mixture of ethyl acetoacetate and formaldehyde as starting materials.
Concept introduction: The reaction of preparation of Hagemann’s ester follows a series of steps. In first step, a base abstracts a proton from the
Want to see the full answer?
Check out a sample textbook solutionChapter 17 Solutions
Organic Chemistry; Organic Chemistry Study Guide A Format: Kit/package/shrinkwrap
- I need help determining the starting materials for these three aldol reactions.arrow_forwardDefine Dehydration of the Aldol Product ?arrow_forwardWhich statement describes why aldol reactions with ketones are low yielding? A.Ketones do not have acidic protons. B.Ketones are too electron poor at the carbonyl carbon. C.Ketones can attack other ketones well but perform poorly in self-condensations. D.The product of a ketone addition to a ketone has considerable steric strain.arrow_forward
- There are other condensation reactions similar to the aldol and Claisen condensations:a. The Perkin condensation is the condensation of an aromatic aldehyde and acetic anhydride. Draw the product obtained from the following Perkincondensation: b. What compound is formed if water is added to the product of a Perkin condensation?c. The Knoevenagel condensation is the condensation of an aldehyde or a ketone that has no a-hydrogens and a compound such as diethyl malonatethat has an a-carbon flanked by two electron-withdrawing groups. Draw the product obtained from the following Knoevenagel condensation: d. What product is obtained when the product of a Knoevenagel condensation is heated in an aqueous acidic solution?arrow_forwardThe Knoevenagel condensation reaction is a variant of the aldol reaction. A major drawback of the aldol reaction is self-aldehyde condensation. Identify the starting material in the Knoevenagel reaction that suppresses self-condensation and explainyour choice.arrow_forwardAldol Condensation What products are formed? What is the difference between aldol reactions and aldol condensation? What type of reaction condentionas are used?arrow_forward
- The aldol double condensation reaction is highly selective for formation of a single double condensation product. Explain why only one aldol condensation product is formed despite two carbonyl compounds being present for the reaction.arrow_forwardWrite the structure for each aldol condensation product that is possible when a mixture of ethanal and propanal is reacted with dilute NaOH.arrow_forwardWrite structures for the carbonyl electrophile and enolate nucleophile that react to give the aldol below. You do not have to consider stereochemistry. Draw the enolate nucleophile in its carbanion form. Draw one structure per sketcher. Add additional sketchers using the drop-down menu in the bottom right corner. Separate multiple reactants using the + sign from the drop-down menu.arrow_forward
- What is the best combination to create a beta-dicarbonyl (1,3-dicarbonyl) compound? a) enolate + aldehyde b) enolate + acid derivative c) enolate + alpha-halogenated carbonyl d) enolate + conjugated carbonyl (Michael addition)arrow_forwardfor the theroretical yield is the mol correct? also using the aldol condensation reaction in this portion are we using the aldol condensation reaction to synthesize acetophenone and para-methybenzaldehye. acetophenone 0.5 g, 4.2 mmol Para-methylbenzaldehyde 0.5 g, 4.2 mmol NaOH=0.18g = 4.5 mol Theroretical yield=0.93g =0.0519 mol Percent yield=76.8% Actual yield= 0.715 g Melting point observered= 93 degree Celsius Expected melting point =93-94.5 degree Celsiusarrow_forwardExplain the following reactions giving one example in each : (i) Cross Aldol condensation(ii) Cannizzaro reaction(iii) Decarboxylation reaction(vi) Kolbe’s reaction(v) Hell-Volhard-Zelinsky reactionarrow_forward
- Organic Chemistry: A Guided InquiryChemistryISBN:9780618974122Author:Andrei StraumanisPublisher:Cengage LearningOrganic ChemistryChemistryISBN:9781305580350Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. FootePublisher:Cengage Learning