CONNECT ACCESS FOR BIOL 01204 <C>
12th Edition
ISBN: 9781264443123
Author: Raven
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Textbook Question
Chapter 17.4, Problem 2LO
Compare and contrast knockout, knockin, and conditional knockout mice.
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Are double-knockout animals (DKOs) and even triple-knockoutanimals (TKOs) also possible ?
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Explain the construction of knockout mice?
Chapter 17 Solutions
CONNECT ACCESS FOR BIOL 01204 <C>
Ch. 17.1 - Prob. 1LOCh. 17.1 - Prob. 2LOCh. 17.1 - Describe the construction and uses of recombinant...Ch. 17.2 - Relate the process of DNA replication to PCR.Ch. 17.2 - Compare and contrast PCR, RT-PCR, and quantitative...Ch. 17.3 - Prob. 1LOCh. 17.3 - Prob. 2LOCh. 17.3 - Describe the pros and cons of RNA interference and...Ch. 17.4 - Explain how the universal nature of the genetic...Ch. 17.4 - Compare and contrast knockout, knockin, and...
Ch. 17.4 - Prob. 3LOCh. 17.5 - Describe the benefits of biofuel production from...Ch. 17.5 - Prob. 2LOCh. 17.5 - Prob. 3LOCh. 17.6 - Prob. 1LOCh. 17.6 - Compare and contrast FISH and gene chip...Ch. 17.6 - Describe how immunoassays can be used to diagnose...Ch. 17.7 - Describe the benefits of creating transgenic...Ch. 17.7 - Prob. 2LOCh. 17.7 - Evaluate issues on each side of the transgenic...Ch. 17 - Prob. 1DACh. 17 - Prob. 2DACh. 17 - Prob. 1IQCh. 17 - Prob. 2IQCh. 17 - You study a gene known to be important in the...Ch. 17 - What is the basis of separation of different DNA...Ch. 17 - Prob. 3UCh. 17 - FISH analysis of a breast tumor biopsy for HER2...Ch. 17 - In terms of studying gene function, what is the...Ch. 17 - The Ti plasmid of Agrobacterium usually induces...Ch. 17 - Prob. 1ACh. 17 - Which of the following statements is accurate for...Ch. 17 - Prob. 3ACh. 17 - Many human proteins, such as hemoglobin, are only...Ch. 17 - Amyloid beta is a proteolytic product of a protein...
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- Name any two diseases for which transgenic mice are used as model organisms.arrow_forwardWhich of the four constructs (Construct 1-4) could be made to make a knockout mouse? For each one not chosen explain why you did not that construct.arrow_forwardThe ability to selectively modify the genome in the mouse has revolutionized mouse genetics. Outline the procedure for generating a knockout mouse at a specific genetic locus. How can the loxP-Cre system be used to conditionally knock out a gene? What is an important medical application of knockout mice?arrow_forward
- What is knockdown gene analysis? How is this different from knockout analysis?arrow_forwardDescribe how you would use replica plating of mutagenized, haploid yeast cells to identify temperature-sensitive (ts) mutations in essential genes needed for yeast growth and survival.arrow_forwardWhat is a fluorophore? If you wanted to fluorescently label a brain cell, describe one way you could genetically label a brain cell using a transgenic approach and give one way you could genetically label a brain cell using a gene targeting homologous recombination approach.arrow_forward
- What is a simple way of making a knockout mouse in terms of DNA recombinant technology?arrow_forwardDiscuss briefly the effects of colchicine treatment on cells. What are the genetic implications of such effects?arrow_forwardhttps://ny.pbslearningmedia.org/resource/biot09.sci.life.gen.epigenetics/epigenetics/ In what way do the brown and yellow mice shown in the video differ?Why is this so?arrow_forward
- During construction of a knockout mouse, a targeting vector is introduced into mouse embryonic cells, where it integrates into the genome at a ["targeted site", "random location"] by ["homologous recombination", "nonhomologous end joining "] . Pick answers within quotation marks to fill in the blanks.arrow_forwardDraw a simplified schematic for Heidelberg screening to identify zygotic genes.arrow_forwardExplain one experimental strategy for determining the functional role of the mouse HoxD-3 gene.arrow_forward
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