Genetic Analysis: An Integrated Approach (2nd Edition)
Genetic Analysis: An Integrated Approach (2nd Edition)
2nd Edition
ISBN: 9780321948908
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 18, Problem 16P

Consider the phylogenetic tree below with three related species (A, B, C) that share a common ancestor (last common ancestor, or LCA). The lineage leading to species A diverges before the divergence of species B and C.

For gene X, no gene duplications have occurred in any lineage, and each gene X is derived from the ancestral gene X via speciation events. Are genes AX, BX, and CX orthologous, paralogous, or homologous?

For gene Y, a gene duplication occurred in the lineage leading to A after it diverged from that leading to B and C. Are genes AY1 and AY2 orthologous or paralogous? Are genes AY1 and BY orthologous or paralogous? Are genes BY and CY orthologous or paralogous?

For gene Z, gene duplications have occurred in all species. Define orthology and paralogy relationships for the different Z genes.

Chapter 18, Problem 16P, 16.16 Consider the phylogenetic tree below with three related species (A, B, C) that share a common

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Molecular marker is used to determine relatedness of species which may directly or indirectly exerts an effect on diversity. A hypothetical ancestor has the following DNA sequences: G A A G C T A T T C A T T. There are two lineage with DNA sequences of G A A G G T A T T C T C G, and G A A C C T A T T C T G C. (1) Determine the percentage of A and T in the DNA sequence of the hypothetical ancestor.  (2) Calculate the percentage of each nitrogenous base in the second lineage.
Which of the following best explains why coalescent-based phylogenetic inference is important in the age of phylogenomics?     A) Coalescent-based methods directly model gene tree histories independently to infer the species tree in a summary-based manner, which is important for phylogenomic analysis were hundreds to thousands of gene histories are analyzed.     B) Coalescent-based methods have the most advanced evolutionary models of molecular evolution, which is important for phylogenomic analysis were hundreds to thousands of gene histories are analyzed.     C) Coalescent-based methods are no more important than other types of phylogenetic inference, even for phylogenomic analyses.     D) None of the above.
Can you answer all the parts to this diagram  Species 1 and 2 are sister species from which you’ve cloned related genes. On the gene tree on the top of the next page, use labels to answer the following questions:  (a) Label the node that represents a gene duplication with “D,” (b) Label the nodes that represent speciation events with “S,”  (c) Pick a pair of genes that are paralogs and label them both “P.” (d) Pick a pair of genes that are orthologs and label them both “O.”

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Genetic Analysis: An Integrated Approach (2nd Edition)

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