To discuss:
Why hemolytic disease of the newborn seldom occurs during the first pregnancy but is more common in later pregnancies, and how it is treated.
Introduction:
The classification of individuals based on their blood types is based on the presence or absence of antigens on the surface of RBCs. These RBC antigens are acquired genetically, and the alleles responsible for these blood groups get passed on from the father and mother to the children. The two main blood typing systems are the ABO system and the Rh system. The ABO system classifies individuals based on the presence of antigens A and B on their RBCs, whereas the Rh blood grouping system classifies individuals based on the presence of antigens, called Rh antigens, on the surface of RBCs. These Rh antigens are completely independent of the presence of the ABO antigens, but the blood types from both these groups are reported together, for example, O˗, AB+, A+, etc., referring to type O, Rh-negative; type AB, Rh-positive; type A, Rh-positive, respectively.
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